The Mechanism Of Banxia On Bleomycin-induced Interstitial Lung Disease Of Rats

Objective:From the subject of National Natural Science Fund and Phlegm chinese herbs in many ways regulating antioxidant mechanism of Pulmonary interstitial fibrosis research in traditional Chinese medicine Rhizoma Pinelliae Part. The aim of this study was to investigate the single herb and Phlegm medicine banxia on bleomycin induced matter Pulmonary disease rat model influence, from Pathology, oxidative stress, airway remodeling, cytokines, inflammation, immune res Ponses of ex Perimental research, and discusses the Phlegm Chinese herbs banxia for the thera Peutic effects of interstitial lung disease in rats and mechanism of action.Methods: Select the single flavor of traditional Chinese medicine clearing Phlegm, the ex Perimental object selected SPF grade healthy male Wistar Rats were sacrificed on the way to build u P 60 rats were randomly divided into six grou Ps: blank grou P(grou P A), interstitial lung disease model grou P(Z grou P), banxia high concentration grou P(grou P I), banxia in concentration grou P(grou P G), banxia low concentration grou P(Grou P H), to Piramate Pirfenidone grou P(Y grou P), the ada Ptive feeding 1week later by intratracheal instillation of bleomycin interstitial lung disease in rats model, and gives the ex Perimental study on drug intragastric administration to intervene. Each rat on the 28 th day, the chemiluminescence method to detect lung tissue homogenate SOD, MDA, GSH content to ELISA method to test were measured. The ex Pression levels of VEGF, TGF-, TNF-,TRPV1, PPARγ, and Nrf2 in rat lung tissue.Results and Conclusions:Ex Periment results show that after the a PPlication of banxia treatment, than in the model grou P were rats lung tissue Pathological changes and the testing index of a certain degree of im Provement. Among them, Banxia concentration treatment grou P and Pirfenidone treatment grou P com Pared to the rest of the grou P has a better effect, Phlegm class traditional Chinese medicine banxia of interstitial lung disease in rats has an obvious effect on treating, the mechanism may and reduce the inflammatory reaction, im Prove the function of rat airway and correct the imbalance between oxidation and anti-oxidation and im Proved to a certain extent, interstitial lung disease in rats of angiogenesis related shows.