The Study Of The Significance Of Serum SP,NGF,IL-2 And IL-4 For Patients With Chronic Idiopathic Urticaria

Objective To study the possible role of substance p (SP), nerve growth factor (NGF), interleukin-2 (IL-2), interleukin-4 (IL-4) in the pathogenesis of chronic idiopathic urticaria (CIU). Methods 59 patients with CIU (including 37 patients with lesion and 22 patients without lesion when then± blood sample were collected) and 26 healthy controls were selected at random. The serum levels of NGF, SP, IL-2 and IL-4 were measured in 59 patients and 26 healthy controls with double antibody sandwich enzyme-linked immuno-sorbant assay. The results were analyzed by statistical package for the social science 8.0(SPSS 8.0). Results (1) The levels of SP in the group of CIU patients with lesion, CIU patients without lesion and healthy controls were 12.47±7.02pg/ml, 9.18±4.46pg/ml, 9.06±4.88pg/ml. The levels of SP in the three groups showed statistically significant difference (p<0.05). The levels of SP in CIU patients with lesion were significantly higher than those in healthy controls and those in patients without lesion respectively (p<0.05). But there was no statistically significant difference between patients without lesion and healthy controls (p>0.05). (2) The levels of NGF in the group of CIU patients with lesion, CIU patients without lesion and healthy controls were 8.72±2.97pg/ml, 8.35±3.42pg/ml, 6.39±1.77pg/ml. The levels of NGF in the three groups showed statistically significant difference (p<0.05). The levels of NGF in CIU patients with lesion and without lesion were significantly higher than those in healthy controls respectively (p<0.05). But there was no statistically significant difference between patients with lesion and without lesion (p>0.05). (3) The levels of IL-2 in the group of CIU patients with lesion, CIU patients without lesion and healthy controls were 6.20±3.68pg/m, 6.73±3.77pg/ml, 9.48±5.59pg/ml.The levels of IL-2 in the three groups showed statistically significant difference (p<0.05). The levels of IL-2 in CIU patients with lesion and without lesion were significantly lower than those in healthy controls respectively (p<0.05). But there was no statistically significant difference betweenpatients with lesion and without lesion (p>0.05). (4) The levels of IL-4 in the group of CIU patients with lesions, CIU patients without lesion and healthy controls were 73.33±27.72pg/ml, 77.35±23.94pg/ml, 34.67±13.38pg/ml. The levels of IL-4 in the three groups showed statistically significant difference (p<0.05). The levels of IL-4 in CIU patients with lesion and without lesion were significantly higher than those in healthy controls respectively (p<0.05). But there was no statistically significant difference between patients with lesion and without lesion. (5)No significant correlation in CIU patients with lesion and patients without lesion were found between the levels of SP, NGF, IL-2 and IL-4. Conclusion (1) The results suggest that SP and NGF may play a role in chronic urticaria and may be the neuogenic factors in chronic idiopathic urticaria (2) The high levels of serum EL-4 and low levels of serum IL-2 may play a role in the pathogenesis of chronic idiopathic urticaria.