Expressions And Clinical Significances Of Serum IL-17 And IL-33 In Chronic Urticaria Patients

Objective:To explore the levels and clinical significances of serum IL-17 and IL-33 in chronic urticaria patients.Methods:Collected 60 cases of patients with chronic urticaria and 60 cases of healthy check-up peripheral blood samples, which patients were derived from the dermatological department of the First Hospital of Shanxi Medical University during December 2014 to May 2015, 29 males, 31 cases were female, age arranged from 11 to 78 years old,average age is 34.1 years old, course of disease is 6 weeks to 5 years, the average is 8.3weeks, all patients are in line with CU diagnostic criteria. The control group of 60 healthy persons were from the physical examination center in the same period, 33 males,27 females, age arranged from 12 to 78 years old, average age is 32.4 years old, all excluded systematic disease and allergic disease history. The selected patients did not use any anti histamine drugs within 3 days, did not have the glucocorticoids and immunosuppressive agents and immune modulators in 1 month. There was no significant differences in sex and age between the two groups. According to UAS method and Dermatology Life Quality Index(DLQI) assessing the patients’ conditions, the content of IL-17 and IL-33 were detected by enzyme linked immunosorbent assay(ELISA) in all the specimens, and by SPSS 19.0 software for statistical analysis, get the correlations of CU patients with IL-17, IL-33 and the severity of the disease and quality of life scores.Results:The serum levels of IL-17 and IL-33 in the patients were Me(25th-75th%)13.26(8.13-19.55)ng/L、249.69(212.26-306.61)pg/ml, and those in the healthy controls were Me(25th-75th%)6.40(4.99-9.26)ng/L、217.62(190.49-251.41)pg/ml,so the serum levels of IL-17 and IL-33 in the patients were significantly higher than those in the healthy controls(P≤0.001), and positively correlated with the disease severity score(r=0.760, 0.444, respectively. both P<0.001), as well as the quality of life questionnaire scores(r=0.679, 0.528, respectively, both, P<0.001).Conclusion:The expressions of IL-17 and IL-33 are elevated in peripheral blood of patients with chronic urticaria, and positively correlated with the severity scores and quality of life questionnaire scores.