| ObjectiveBy observing the clinical effect of Qi Jingmingmu decoction combined with artificial tears in the treatment of dry eyes,the effective methods of local treatment and whole body conditioning of dry eyes were found.MethodsIn this study,120 patients with dry eyes with deficiency of liver and kidney yin(age 40 ? 80 years old)were randomly divided into treatment group(Qi Jingmingmu decoction combined with artificial tears group)and control group(artificial tears group).The course of treatment was 3 months before treatment,1 month after treatment,2 months after treatment,and 3 months after treatment to observe the rupture time of tear film,tear secretion function,lacrimal river height,corneal fluorescein staining,tarsal gland function,international eye surface disease index.The syndrome integral of traditional Chinese medicine(TCM)was evaluated by variance analysis of repeated measurement design data.Results1.A total of 120 patients with dry eyes were enrolled in this study,60 patients in the treatment group and 60 patients in the control group.There was no significant difference in age,sex and clinical baseline characteristics between the two groups.It was comparable(P > 0.05).2.Curative effect judgment: the total effective rate was 95.0% in the treatment group and 73.3% in the control group,the difference was statistically significant by chi-square test(P = 0.001).For TCM syndromes,the total effective rate was 95.0% in the treatment group and 21.7% in the control group,with significant difference by chi-square test(P < 0.001).3.Breakup Time: The breakup time before treatment was(4.17 ±1.24)in the treatment group and(4.17 ±1.08)in the control group(F = 0.000,P = 0.984).There was significant difference in BUT between the two groups at different time points(P < 0.001).4.Schirmer I Test:The Schirmer I test of the treatment group(7.03 ±0.78)was better than that of the control group(7.00 ±1.22)(F = 0.032,P = 0.859).There was significant difference in tear secretion function between the treatment group and the control group(P < 0.001),and there was significant difference between the treatment group and the control group at different time points(F = 473.292,P < 0.001).There was no significant difference in the results at different time points in the control group(F = 3.740,P = 0.058).5.Tear Meniscus Height:The tear meniscus height in the treatment group(0.15 ±0.02)was better than that in the control group(0.16 ±0.02)(F = 0.663,P = 0.417).There was significant difference in TMH between the two groups at different time points(P < 0.001).6.Fluorescent:Before treatment,the treatment group(1.17 ±0.38)was more balanced than the control group(1.30 ±0.46)(F = 3.006,P = 0.086).There was no significant difference between the treatment group and the control group after 1 month,2 months and 3 months after treatment,but there was significant difference between the two groups at different time points(P < 0.001).7.Meibomain Gland Dysfunction:The function of meibomain gland: there was no significant difference between the treatment group(2.10 ±0.30)and the control group(2.10 ±0.30)before treatment(F = 0.013,P = 0.892).After the treatment for 1 month,2 month and 3 month,the difference between the treatment group and the control group was statistically significant(P <0.001).The results of different time points in the treatment group were statistically significant(F = 574.995,P <0.001),and the difference of the measured results in the control group was not statistically significant(F = 2.786,P = 0.100).8.International ocular surface disease index: there was no significant difference between the treatment group(22.37 ±1.19)and the control group(22.02 ±1.33)before treatment(F = 2.295,P = 0.132).There was significant difference in OSDI between the two groups at different time points(P < 0.001).9.TCM syndrome score:The score of TCM syndromes before treatment was(19.22 ±0.89)in the treatment group and(19.37 ±0.78)in the control group(F = 0.970,P = 0.327).There was significant difference in TCM syndrome scores between the two groups at different time points(P < 0.001).Conclusions1.The Qi Jingmingmu decoction combined with artificial tears is more effective than artificial tears alone in the treatment of dry eyes.2.The Qi Jingmingmu decoction can not only improve the local conscious symptoms of dry eyes,improve the stability of tear film,promote tear secretion,repair corneal epithelial and improve the function of tarsal gland secretion.3.The Qi Jingmingmu decoction can improve the systemic symptoms of dry eye patients,and the effect becomes more and more significant with the prolongation of time nodes,which can achieve the therapeutic effect through local medication and whole body conditioning. |
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