The Study On The Prime Correlation Of Infantile Eczama

Objective: This paper explores the relationship among cord blood’s total IgE levels,family history of allergic diseases and infantile eczema; finds out high risk factors ofinfantile eczema; and searches the methods of early preventing and intervening infantileeczema and other allergic diseases.Method: This paper selects241neonates born from December2011to December2012in Zhifu District Maternal and Child Health Hospital, gestational age at37-42weeks. After delivery of fetus,2-3ml Umbilical vein blood is drawn in fetal end andserum after centrifugation, which are reserved﹣20℃. Application ofenzyme-linked immunosorbent assay (ELSIA) sandwich quantitative detection methoddetermines cord blood’s total IgE levels and records total IgE value. One paper file isestablished under the name of newborns’ mothers, where parents’ history of allergicdiseases is inquired and infant feeding, introduction of solid food, diagnosis andtreatment of eczema are recorded at three different times, i.e. infants’ one month, threemonths and six months old. The paper conducts chi-square test and statistical analysisof significant difference over the relationship between history of allergic diseases andinfantile eczema morbidity, between cord blood’s total IgE levels and infantile eczemamorbidity. This paper also conducts statistical analysis of differences related to rankover cord blood’s total IgE levels of infants with and without eczema.Result:�'�Among241infants,160suffer from eczema, accounting for66.39%;81not,accounting for33.61%. Among160infants infantile eczema,134are diagnosed with itat the age of one month, accounting for83.75%;14at the age of3months, accountingfor8.75%;12at the age of six months, accounting for7.5%.�'�Among108infants with history of allergic diseases,83suffer from eczema,accounting for76.85%. Among133infants without history of allergic diseases,77suffer from eczema, accounting for57.89%. According to independent sample chi-square test, the incidence of eczema with and without history of allergic diseases isX2＝9.6，p<0.05. The difference is statistically significant.�'�Among134infants diagnosed with eczema at their one month old,70havefamily history of allergic diseases,56haven’t the symptom temporarily at the age of sixmonths, accounting for80%;64haven’t family history of allergic diseases,56recoverat the age of six months, accounting for87.5%. According to independent samplechi-square test, the difference of eczema symptom’s temporary disappearance ratebetween infants with and those without family history of allergic diseases is X2＝1.37，P＞0.05, which is not statistically significant.�'�All241infants receive determination of total IgE of umbilical cord blood. Thereare142infants whose total IgE is between0and0.5IU/ml,92suffering from eczema,the incidence rate is64.79%; there are45infants whose total IgE is between0.5and1.0IU/ml,31suffering from eczema, the incidence rate is68.89%; there are27infantswhose total IgE is between1.0and1.5IU/ml,19suffering from eczema, the incidencerate is70.376%; there are15infants whose total IgE is between1.5and2.0IU/ml,9suffering from eczema, the incidence rate is60%; there are12infants whose total IgEis equal or greater than2.0IU/ml,9suffering from eczema, the incidence rate is75%;According to independent sample chi-square test, X2＝1.14，p﹥0.05, the difference isnot statistically significant.�'�By the rank correlation analysis, cord blood’s total IgE of infants with andwithout family history of allergic diseases is T1＝7801.5，T2＝21359.5，Z＝-1.694，P＝0.09.The difference is not statistically significant.�'�According to independent sample rank test, cord blood’s total IgE of infants withand without eczema is T1＝9493.5，T2＝19667.5，Z＝-0.602，P＝0.547. The differenceis not statistically significant.Conclusion:�'�The total incidence of eczema in Yantai is relatively high, accounting for66.39%. The age of onset becomes younger. The incidence rate of eczema reaches83.75%among one-month infants.�'�The incidence of infantile eczema is high.Family history of allergic diseases isthe high risk factor of infantile eczema.�'�Family history of allergic diseases is not associated with cord blood’s total IgE.Mathernal total IgE can not pass through placenta.�'�The incidence of infantile eczema is not associated with cord blood’s total IgE.