Correlation Between The Levels Of IL-13 And Eotaxin In Umbilical Cord Blood And Early Infantile Eczema

Infant eczema is the most common early allergic skin disease.Genetic and immune factors are considered to be important factors affecting eczema.The infant’s immune system as early as in the mother during pregnancy palace began to development,and index of immune inflammatory reaction of neonatal of umbilical cord blood,as the immune function of state,therefore,research the composition such as umbilical cord blood immune inflammatory factors associated with the onset of infant eczema,helps to reveal the influence factors of infant eczema,early prevention of infant eczema has the positive significance.Studies have confirmed that IL-13 and Eotaxin play a key role in the pathogenesis of eczema,and the levels of IL-13 and Eotaxin in the blood of patients with eczema are significantly increased.However,there are few studies on the relationship between the levels of IL-13 and Eotaxin in umbilical cord blood and infant eczema.This study analyzed the relationship between the levels of IL-13 and Eotaxin in umbilical cord blood and early infantile eczema,and explored the related factors affecting infantile eczema.Included in the object of this study is derived from October 2018 to May 2020 in the Air Force Medical Center of PLA of obstetrics and gynecology medical center was born and incorporated into the standard 264 newborns,collected 5 ml after their birth in the umbilical cord blood in blood vessels.In our hospital clinical laboratory after centrifugal separation of plasma,use enzyme-linked immunosorbent assay(enzyme linked immunosorbent assay,ELISA)to detect umbilical cord blood IL-13,Eotaxin level.The basic information of 264 newborns and questionnaires were recorded to investigate the maternal pregnancy and family history of allergic diseases.The infants were followed up 42 days after birth for eczema,the severity of the eczema was assessed,and the mothers were asked about their diet and feeding patterns during lactation.SPSS 25.0statistical software was used for data analysis,and P < 0.05 was considered statistically significant.Among 264 newborns in this study,cord blood IL-13 levels were15.35±11.66 pg/ml and Eotaxin levels were 107.59±66.32 pg/ml.151 infants had eczema and 113 infants had no eczema at 42-day follow-up,and the prevalence of eczema was 57.2%.Infants were divided into eczema group and no eczema group according to whether they had eczema or not.There were statistically significant differences between the two groups in terms of whether they had family allergy history,feeding pattern,whether mothers ate seafood,nuts,peanuts,soy products,beef and mutton food during lactation(P<0.05),while there were no significant differences in the baby’s sex,birth length and weight,gestational age,delivery mode,father’s age,mother’s age and whether the pregnancy was healthy or not(P>0.05).The levels of IL-13 and Eotaxin in umbilical cord blood in the eczema group were significantly higher than those in the non-eczema group,and the differences were statistically significant(P < 0.05),indicating that the levels of IL-13 and Eotaxin in umbilical cord blood were closely related to the occurrence of eczema in infants.There were statistically significant differences in the levels of IL-13 and Eotaxin in umbilical cord blood between the two groups(P<0.05),indicating that the family history of allergy has a certain influence on the levels of IL-13 and Eotaxin in umbilical cord blood.There was no significant correlation between umbilical cord blood IL-13 and Eotaxin(P>0.05).Kruskal-Wallis test was used to analyze the levels of IL-13 and Eotaxin in umbilical cord blood of mild,moderate and severe eczema,and the differences were not statistically significant(P > 0.05).Infant eczema was divided into two groups according to the onset time of infant eczema on day 42,which was divided into 1-3 weeks group and 3-6 weeks group.There was no statistical significance in the levels of IL-13 and Eotaxin in umbilical cord blood between the two groups(P > 0.05).Logistic stepwise regression analysis was performed with umbilical cord blood IL-13,Eotaxin and family history of allergy as independent variables.The results showed that high expression levels of IL-13 and Eotaxin in umbilical cord blood and family history of allergy were important risk factors for eczema,and the differences were statistically significant(P<0.05).The levels of IL-13 and Eotaxin in umbilical cord blood are closely related to infantile eczema,and the high expression of IL-13 and Eotaxin in umbilical cord blood is a risk factor for infantile eczema.There was no significant correlation between the expression levels of IL-13 and Eotaxin in umbilical cord blood and the severity of eczema in infants.Family history of allergy,mixed feeding,and mother’s feeding of seafood,nuts,peanuts,beef and mutton,soy products are important risk factors affecting the incidence of eczema.