Analysis Of Microbial Infection/Colonisation Stations And Evaluation Of Treatment To Different Types Of Infantile Eczema

Infantile eczema(IE)is one of the most common allergic skin diseases in infants.Its etiology and pathogenesis are complex.There is a certain correlation between IE and the microbial infection or colonization at skin surface.This study is to investigate the microflora in skin lesions of infants with different types of eczema(IE),analyze the relationships between microflora and IE,then evaluate the efficacy of different drugs in the treatment of IE,and to provide evidence for early prevention and effective treatment to it.168 cases were randomly selected from Department of Dermatology,First Affiliated Hospital of Hebei North University.Divided them into three types according to the lesions,there were 62 cases in exudative type,77 cases in seborrheic type and 29 cases in dry type.Selected 30 control infants at the same time.Then isolation rates of microflora were analyzed in lesional and non-lesional skin of infants with IE and skins of healthy infants and the culture rates of microflora in different types of IE were compared.After diagnosis and classification,and according to the preliminary experiment,patients of exudative type were randomly divided into treatment group and control group,all were first treated by 0.9% saline solution for 2-4 days,when the lesions got dry,desonide cream and fusidic acid cream were used in treatment group and desonide cream was used only in control group for twice a day.For patients of seborrheic type and dry type,were mixed and then randomly divided into treatment group and control group,desonide cream,naftifine hydrochloride and ketoconazole cream were used in treatment group anddesonide cream was used only in control group for twice a day.The clinical effects and eczema area,severity index(EASI)scores were measured after7 days and 14 days of therapy,the cytokines(IL-1?IL-6?TNF-?)levels were measured just after 14 days.SPSS 17.0 statistical software was used for statistical analysis.Studies showed that,(1)The isolation rates of staphylococcus aureus(SA),malassezia furfur(MF)and streptococcus phages(SP)in skin lesions of IE were significantly higher than that in non-lesions of IE and skins of healthy infants(P < 0.05),while no significant differences of staphylococcus epidermidis(SE)were found among them.Different microfloras were found in different types of IE.(2)The exudative type exhibited a significant higher culture rate of SA than seborrheic type and dry type(P < 0.05).The seborrheic type and dry type both showed significant higher culture rates of MF than the exudative type(P < 0.05),while no obvious difference of MF was found between the former two.(3)Both for 7 d and 14 d after therapy,the effective rates of the treatment group were significantly higher than that of the control group(P < 0.05),the EASI scores and levels of the three cytokines of the treatment group were significantly lower than that of the control group(P < 0.05),moreover,no significant adverse reaction was observed in both the treatments.These results suggest that,(1)The infection or colonization of microflora(e.g.SA and MF)is closely related to IE.(2)There are certain differences of microflora among different types of IE,which may suggests that different microbial types may lead to or aggravate different types of IE.(3)Appropriate use of different antimicrobial drugs according to the types of IE can significantly improve the efficacy and reduce recurrence in the treatment of it.