| Study Background and Objective:Chronic atrophic gastritis is a common disease of digestive system, It is a hotspot of digest field in recent years.CAG is gastric gland atrophy as the main performance inherent in the chronic inflammation, CAG in the gastric lesions precancerous occupy an important position, their movement through the multi-stage, multi-gene mutation accumulation process can be developed into the stomach. Its pathogenesis is not yet clear, with the in-depth study of the CAG, CAG foreign scholars put forward the development and changes in gastric cancer in the evolution of key links have been has been clearly identified as precancerous lesions. Due to the long course of the disease, Western medicine is still a lack of specificity of an ideal treatment method, etc. In recent years, the area from the use of traditional Chinese medicine theory, Chinese medicine treatment of CAG, a large number of reports that Chinese medicine has a clear reversal of the role of CAG, This study to observe the effect of Clove wei ling Mixture on the gastric mucosa level of IL-2,Bcl-2 and gastric mucosa Pathological histology in rats model of Chronic Atrophic Gastritis, and to explore the mechanism of Clove wei ling Mixture in the treatment of CAG.Material and Method:Sixty Wistar rats were randomly divided into Five groups (male and female half and half):normal control group, model control group, Clove wei ling Mixture low-dose group, Clove wei ling mixture middle-dose group and Clove wei ling mixture high-dose Group,12 in each group. Modeling methods:the normal control rats given normal saline, the other groups were administered with sodium salicylate, free drink ammonia, with irregular diet animal model was established by CAG, all the factors were given for two months. after the success of the intervention modeling experiment, Except normal control group rats and model control group, others were treated with different dose clove wei ling mixture for six weeks. Their gastric juice was collect to detect PH value with PH test paper, their blood serum of eyeball was collect to detect IL-2 with IL-2 Elisa kit IL-2 content; their stomachs were collect to detect Bcl-2 by immunohistochemistry to detect Bcl-2 in gastric mucosal expression. detect the gastric mucosa changes by light microscopy. All experimental data application SPSS 16.0 for windows statistical software for statistical analysis, P<0.05 as statistically significant, P<0.01 as statistically significant.Results:Compared to normal control group, PH value of gastric juice,the quantity of IL-2 and expression of Bcl-2 in the model control group was significantly higher, the difference was statistically significant (p<0.01),and pathological changes are quite; Compared to model control group, those rats were treated with different dose Clove wei ling mixture for six weeks, there was significant statistics difference in pathologic changes of gastric mucosa. Compared to model control group, PH value of gastric juice,the quantity of IL-2 and expression of Bcl-2 of high-dose Clove wei ling mixture group, middle-dose Clove wei ling mixture group and low-dose Clove wei ling mixture group was lower, the difference was statistically significant (p<0.01).Conclusion:IL-2 mediated inflammatory and immune response and inhibition of Bcl-2 Apoptosis is the pathogenesis of CAG. Clove wei ling mixture can adjust significantly level of the quantity of IL-2 and expression of Bcl-2. Protection of gastric mucosa injure is a important factor induced CAG, And Clove wei ling mixture have protective functions against the gastric mucosal injure, even can turn over partly the pathologic changes of gastric mucosa, It is a important factor induced Chronic atrophic gastritis...
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