Studies On The Construction Of Acute Pancreatitis Pathology Model And Its Clinical Treatment

[Objective] Discussing about construction of canine acute pancreatitis pathology model and treatment with "qingkailing" .[Methods] A total of 20 dogs were randomly assigned to 5 treatment groups which were charge group, AP group, "qingkailing" group 1, "qingkailing" group 2 and regular treatment group. The cases modeling was building by antidrom-injecting compounds trypsin and Sodium Cholate into canals of wirsung. Then every dog of each group was treated 1 time by regular medicine every day. Every dog was sampled blood from jugular vein on 1^st day, 2^nd day, 4^th day and 7^th day after the case model was building in order to monitoring the variation of ET, MDA, SOD and AMY. And 7 days later, specimen from splanchna were sampled for bacterial culture to study the bacterial translocation and pathology. In order to approach the dose-effect relationship of radical scavenging and ET scavenging to "qingkailing" .[Results] Severe hyperaemia and hydropsia of pancreas could be seen after injecting sodium cholate. The difference of Plasma amylase between charge group and other groups was extremely significant. ET and MDA were increased with time after acute pancreatitis happened. Body temperature was aroused higher by ET while "qingkailing" made it lower. The diffirence effect of radical scavenging and ET scavenging and bacterial translocation was significant. There' s no significant difference between "qingkailing" group 1 and "qingkailing" group 2. the difference between AP group and other 3 treatment group.[conclusion] Case model of acute pancreatitis could be builded by injecting sodium cholate and compounds trypsin. ET and free radicle could be scavenged, translocated bacterial could be reduced pathological changes could be relieved and body temperature could be lower significant by injecting "qingkailing" . "qingkailing" is a usuful medicine on clinical.