Gentian Purging Liver Soup Treatment Of Gallbladder Relieving Wind-cold Type Chronic Nasal Sinusitis Randomized Controlled Study

Purpose:The randomized controlled clinical study is conducted to observe the the clinical curative effect and safety of longdan xiegan decoction in the treatment of chronic rhinosinusitis in patients with depressed gall-bladder with phlegm-heat through Quality of Life Scale.Method:60patients of chronic rhinosinusitis with depressed gall-bladder with phlegm-heat were randomly divided into treatment group and the control group.Subjects received either longdan xiegan decoction daily for2weeks or decoction placebo.Outcome measures included the Sinonasal Outcome Test-20(SNOT-20), VAS scale,SF-36scale,measurements of Lund-Kennedy endoscopic scoring,and nasal lavage assays for interleukin-8. All statistical data is Statistical analysis was performed using the SPSS software. Data are expressed as mean standard error of mean. An intention-to-treat analysis was used. The Mann-Whitney U test was applied to the patient response scale data. The Wilcoxon signed rank test was applied to the remaining data. P values<0.05were considered significant.Results:There were statistically significant improvements in SNOT-20score and VAS scale as well as IL-8levels in lavage fluid (P<0.05) in the longdan xiegan decoction group. No significant improvements were noted for Lund-Kennedy endoscopic scoring, SF-36scale.Conclusion:Through the preliminary clinical study, longdan xiegan decoction plays a significant role in the improvement of clinical symptoms to reduce the pain index, lower inflammatory activity, enhance the quality of life, Additional studies are required to assess their place in clinical practice.