Cohort Study About Correlation Between Helicobacter Pylori Infection And Nonalcoholic Fatty Liver Disease

Background: Previous studies have suggested an association between Helicobacter pylori(H.pylori)infection and nonalcoholic fatty liver disease(NAFLD),yet the results are controversial.Methods: A cohort study of 2063 adults without NAFLD at baseline,who participated in a repeated health check-up including a 13 C urea breath test,was conducted to evaluate the link between H.pylori infection and NAFLD development.Fatty liver was diagnosed by ultrasonography.Regression analysis was used to determine the association between Helicobacter pylori infection and NAFLD.At the same time,multivariate regression analysis was performed to determine the effect of other indicators other than Helicobacter pylori on NAFLD.Finally,I did a stratified analysis to determine whether the effects of Helicobacter pylori infection on NAFLD were different under different age,gender,and body mass index stratification.Results: In a multivariable model adjusted for all potential confounding factors,I found that there were no association between H.pylori infection and NAFLD,the odds ratio was 1.18,95% CI=0.88-1.59,P=0.2730.We found that Age,BMI,SBP,DBP,FBG,TG,TC,LDL-C,ALT,AST,GGT were all risk factors for NAFLD development,and Protective factor was a Protective factor.In subgroup analysis stratified by sex,age and BMI,we found the results in the elderly and overweight population were significant.The odds risks for them were 2.090(1.157,3.778),p=0.0146 and 1.545(1.012,2.360),p=0.0440 respectively.Conclusions: H.pylori infection was not associated with the risk of NAFLD in the whole population,but in the elderly and overweight population,it might play a role in NAFLD development.