Correlational Study Between Salivary Cortisol And Secretory Immunoglobulin A And Psychological Symptoms Of Minor Aphthous Ulcer Patients

Objective:To investigate the relationship between psychological symptoms of minor aphthous ulcer(MiRAU)patients and the correlation with the levels of salivary cortisol and Secretory immunoglobulin A(SIgA).Methods:Fifty patients with MiRAU were selected as MiRAU group.Another thirty healthy persons were recruited as control group.Collecting the saliva sample of MiRAU group and control group between 8.00 am and 10.00 am.Mental health level of both groups were respectively evaluated by Symptom Checklist 90(SCL-90).The method of ELISA was used to detect the levels of salivary cortisol and SIgA.Though statistics to compare the difference between salivary cortisol,Secretory immunoglobulin and 10 factors in Symptom Checklist 90,analyzing the correlation among the scores of 10 factors in Symptom Checklist 90 and the levels of salivary cortisol and SIgA.Results: 1 Scores of obsession,depressed and anxiety of MiRAU patients in SCL-90 were significantly higher than those of the normal control,the difference was statistically significant(p<0.01).Scores of interpersonal sensitivity and paranoid were higher than those of the normal control,the difference was statistically significant(p<0.05).Proportion of positive symptom in obsession,depressed and anxiety of SCL-90 in MiRAU patients were higher.2 The level of salivary cortisol inMiRAU group was 99.79±5.34?g/L,which significantly higher than the controls 80.49±4.19?g/L,the difference was statistically significant(p<0.01).The level of SIgA in MiRAU group was 22.89±1.49?g/mL,which significantly lower than the controls 28.59±1.36?g/mL,the difference was statistically significant(p<0.01).3 The level of salivary cortisol was correlated with level of SIgA,and was the negative correlation(r=?0.535,p<0.05);Scores of obsession,depressed and anxiety in with MiRAU were correlated with the level of salivary cortisol,and were the positive correlation(obsession r=0.558,p<0.05;depressed r=0.545,p<0.05;anxiety r=0.436,p<0.05).Score of obsession,depressed and other factors were correlated with level of SIgA,and was the negative correlation(obsession r=?0.549,p<0.05;depressed r=?0.497,p<0.05;others r=?0.418,p<0.05).Conclusion: 1 The occurrence and development of MiRAU are related to psychological factors such as anxiety and depression.MiRAU patients? psychological status can be understood by Symptom Checklist 90 clinic.2 Stress response can lead to a rise in the level of saliva cortisol.The relationship between MiRAU and psychological factors can be evaluated by detecting the level of saliva cortisol.3 The patients in a persistent or greater stress condition,which may lead to the decrease the local immune function of the body or oral cavity.It may be one of the causes of MiRAU.