Correlation Between Anxiety,Depression And Salivary Cortisol And SIgA In Patients With Burning Mouth Syndrome

Objective:By studying the anxiety and depressive symptoms,the expression of salivary cortisol and secretory immunoglobulin A(SIgA)of patients with Burning Mouth Syndrome(BMS)and analyzing their correlation.Further explore the possible etiology and pathogenesis of BMS,and provide a new basis and ideas for clinical diagnosis and treatment of burning mouth syndrome.Methods:We selected 30 patients who were admitted to The First Hospital of Shanxi Medical University from January 2018 to December 2018 and whose clinical diagnosis was Burning Mouth Syndrome(BMS)as the experimental group;And 30 healthy controls were selected.The unstimulated saliva was collected from 8:00 to 10:00 in the morning,and the anxiety and depression status of the subjects were assessed using the Self-rating Anxiety Scale(SAS)and the Self-rating Depression Scale(SDS).The levels of cortisol and secretory immunoglobulin A(SIgA)in saliva samples were detected by enzyme-linked immunosorbent assay(ELISA).The t-test was used to compare the anxiety,depression,cortisol and SIgA levels in the experimental and control groups.Correlation between indicators is measured by the pearson correlation coefficient.Results:1.The scores of anxiety and depression in the BMS group were 50.79±7.77 and52.70±7.78,respectively,which were significantly higher than those of the normal control group(32.87±4.63,34.00±3.35).The difference was statistically significant(P<0.05).2.The salivary cortisol level of BMS group was 89.42±12.33ng/ml,which was significantly higher than that of healthy control group(77.86±6.89ng/ml),the difference was statistically significant(P<0.05).The SIGA level of BMS group was 51.70±7.96?g/Ml was significantly lower than the healthy control group at 78.80±5.85 ?g/ml,and the difference was statistically significant(P<0.05).3.There was a negative correlation between salivary cortisol level and SIgA level,and the correlation coefficient was statistically significant(r=-0.440,P<0.05).Salivary cortisol level was positively correlated with anxiety and depression scores,and the correlation coefficient was statistically significant(anxiety r=0.350,P<0.05);depression r=0.419,P<0.05);salivary SIgA level was negatively correlated with anxiety and depression scores,and the correlation coefficient was statistically significant(anxiety r=-0.736,P<0.05;depression r=-0.788,P < 0.05).Conclusion:1.The incidence of BMS is closely related to anxiety and depression.Clinically,patients should be psychologically intervened while taking medication.2.Stress states such as anxiety and depression can cause elevated levels of salivary cortisol.Clinically,salivary cortisol levels can be used as an effective means to assess the relationship between BMS onset and psychological factors.3.Long-term negative emotions such as anxiety and depression make BMS patients in a state of psychological stress,causing a decrease in salivary SIgA levels in BMS patients and a decrease in oral local immune function,which is one of the important causes of BMS.