Clinical Study On The Therapeutic Effect Of Pediatric Kechuanning Oral Liquid On Bronchitis In Children

ObjectiveThrough clinical randomized controlled trials to observe the different doses of pediatric Kechuanning oral solution for the treatment of children with acute bronchitis clinical efficacy and to explore the relationship between its efficacy and safety so as to further refine the dose of pediatric Kechuanning oral liquid for the specialist preparation.MethodsSixty-five children with acute bronchitis(wind phlegm retention in the lung)who meet the diagnostic criteria of Chinese and Western medicine were selected and randomly divided into low,medium and high dose groups and the control group.The control group were given routine treatment.The experimental group was treated with low,medium and high dose of Kelechuanning oral liquid on the basis of routine treatment for 5 days respectively.The changes of respiratory symptoms and signs before and after the four groups were observed.According to the Guiding Principles of Clinical Research of New Drugs of Traditional Chinese Medicine(for Trial Implementation),the respiratory symptoms,signs and symptoms of Chinese medicine were scored daily,and the curative effect was evaluated on the third day of treatment and after the end of treatment(refer to Zheng Xiaoyu's edition 2002 "Chinese new drug clinical guidelines(Trial)evaluation criteria for the development of statistical analysis of all data are used SPSS software version 17.0,measurement data with mean ± standard deviation,multiple observation group measurement data using one-way ANOVA;count data.Expressed as a percentage,using ?2 test or Fisher test;rank data using rank sum test.ResultsNo adverse reactions occurred in any of the four groups of children during the treatment.After 3 days of treatment,all four groups started to work,butthe total effective rate was lower than 60%.The efficacy of the four groups was tested by rank sum test,P>0.05,and the difference was not statistically significant.After the treatment was completed,the mean value of the efficacy index in the three treatment groups was higher than that in the control group.The mean value of the efficacy index in the high-dose group and the middle-dose group was greater than that in the low-dose group.After single-factor analysis of variance,P<0.05,the difference was statistically significant.The efficacy indexes of the high and middle dose groups were P>0.05,and there was no statistically significant difference.the total effective rate was 88.2%in the low-dose group;the total effective rate was 93.7% in the middle-dose group;the total effective rate was 93.7% in the high-dose group;and the total effective rate was 87.6% in the control group.After rank sum test P<0.05,the difference was statistically significant.ConclusionPediatric Kechuanning oral solution for the treatment of children with acute bronchitis(wind phlegm retention in the lung)clinical curative effect,non-toxic side effects,can significantly improve the respiratory symptoms and signs.The study confirmed that with the increase of pediatric Kechuanning oral dosage,clinical efficacy increased,reaching a certain amount,the efficacy tends to be stable,indicating the existence of dose-effect relationship,At the same time,this study shows that the use of refined doses at middle-age doses is effective and safe.Therefore,it is recommended that the clinical use of Pediatric Kechuanning Oral Liquid can be quantified with reference to the middle-dose age,but the optimal dose is still needed further clinical studies.