| This paper includes two parts of literature review and clinical research.The literature review consists of 2 parts,the first part is the review,review the research progress of Western medicine recognition and prevention of hand foot syndrome,including common chemotherapy drugs and handfoot syndrome of capecitabine and clinical application of hand foot syndrome pathogenesis,clinical manifestations,diagnostic criteria and classification status of Western medicine comprehensive prevention of hand foot sign.Hand foot syndrome is one of the most common adverse reactions of capecitabine chemotherapy process,mainly for sensory disturbance and palmoplantar erythema,severe visible ulcer,desquamation and severe pain.Hand foot syndrome reduces the quality of life of patients,but also affect the smooth progress of capecitabine chemotherapy,often lead to drug reduction or interruption of treatment,a serious impact on the expected clinical efficacy of chemotherapy.Modern medicine has made a meaningful exploration on its pathogenesis,but has not yet reached a consensus.In treatment,advocate general treatment and health education,nursing and other local vitamin B6,cyclooxygenase inhibitor,DPD enzyme inhibitors and other drugs,but the treatment effect is not ideal,is not satisfied with the clinical efficiency,need to be further exploration and research.The second article review of Chinese medicine,reviewed the understanding of Chinese medicine on hand foot syndrome,and in recent years the study of hand foot syndrome of Chinese medicine in the prevention and application of traditional Chinese medicine in different clinical forms made a preliminary summary,including topical agent,oral agent,injection and moxibustion etc..This paper summarized the clinical application of external preparation,such as external lotion,fumigating lotion,oil agent,powder,paste,etc..Traditional Chinese medicine preparation has good curative effect and side effect,and is widely used in the prevention and treatment of hand foot syndrome.A large number of scholars based on clinical observation confirmed that traditional Chinese medicine has unique advantages and disadvantages of hand foot syndrome.However,the understanding of the disease is different from each other,the treatment is not the same,we still need to further explore and explore.This paper discusses the clinical observation from several aspects.The adverse reaction of special physical tumor patients caused by chemotherapy and capecitabine based on the hand foot syndrome to investigate the pathogenesis of "blood stasis,heat and toxin accumulating hard,off in the hand and foot collaterals,injury by reinforcement","stasis and syndrome of heat invading collaterals".To determine the "blood stasis,clearing heat,detoxification treatment method,choose the representative prescription of Xian Fang Huo Ming Yin Qingrejiedu based drug selection,chmical process,research into external Decoction clinical intervention,in order to study on the treatment of HFS,provides the method and the way new for the prevention and treatment of HFS.In clinical research,we observed and summarized the clinical effect of the treatment of hand foot syndrome caused by capecitabine.[Objective]Objective To observe the clinical efficacy and safety of external application of modified Xian Fang Fang Yin in the treatment of hand foot syndrome.[Methods]According to the inclusion criteria,30 cases of tumor patients in capecitabine chemotherapy.Methods before and after treatment,treated with the modified by xianfanghuomingyin frying bath we brothers,30min each time,2 times a day,sooner or later each time.Warm bath after the application of the external parts of the charge,each 30min,2 times a day.7 days for a total of 1 courses,a total of 2 courses of treatment.Before and after treatment,hand foot syndrome grading score,clinical symptom score,pain score and general state score were used to evaluate the efficacy and safety.[Results]In 30 patients,a clinical classification of 18 cases of patients with HFS decreased,8 patients remain stable;there are 26 cases of patients with clinical symptoms were alleviated,the total effective rate was 86.67%(26/30);pain the total remission rate was 90%(27/30),the complete remission rate was 36.67%(11/30);the general state(and appetite sleep,emotion,spirit)the total improvement rate was 80%(24/30).And there were no adverse reactions such as skin allergy and rashes before and after treatment.The data comparison,P values were 0.05,the difference was significant.[Conclusion]The clinical effect of the external use of modified Xian Fang Fang Decoction on the treatment of hand foot syndrome caused by capecitabine chemotherapy is safe,and it is worthy of further clinical study. |
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