Warm The Meridians Topical Treatment Of Chemotherapy-induced Peripheral Nerve Toxicity And Hand-foot Syndrome In Clinical Studies

This dissertation is composed of two parts: the review articles and a clinical research.There are two review articles. The first one reviewed the experimental and clinical research about peripheral neurotoxicity caused by Oxaliplatin, and the second one is about hand-foot syndrome caused by Capecitabine. They mainly conclude clinical symptoms, pathological changes, grading standards, regularities, pathogenesis and the development of management in TCM and Western Medicine.The second part is a clinical study. Objective:To investigate the effect of the external use of Wenjing Tongluo treatment in peripheral neurotoxicity and hand-foot syndrome caused by chemotherapy. Methods:27 patients with peripheral neurotoxicity or hand-foot syndrome,which were caused by chemotherapy drugs,such as Oxaliplatin,Capecitabine and Paclitaxel. All the patients washed and soaked the diseased regions by Wenjing Tongluo treatment warmly,20 minutes every time,twice daily,7 days as a cycle. Results:27 patients were studied, 25 patients showed very good response , symptoms were relieved and last shorter .The effective rate and significant effective rate were 92.6%(25/27)and 66.7%(18/27).Conclusion: The external use of Wenjing Tongluo treatment could treat peripheral neurotoxicity and hand-foot syndrome induced by chemotherapy, which is worthy of a further research in oncological clinic.