The Clinical Observation Of The Chinese Herb Therapy Capecitabine Capecitabine Induced Hand-foot-syndrome

This dissertation is composed of two parts:a review article and a clinical research.The review article is about the advances in the treatment of hand-foot syndrome caused by Capecitabine in recent years.It includes clinical symptoms,pathogenesis, pathological features,and the development of management in TCM and Western Medicine.Aggregate analysis,hand-foot syndrome is one of the main side effects caused by Capecitabine,which influences the patients' quality of life seriously.Many scholars have paid attention to hand-foot syndrome.According to the clinical observation,it proved that TCM is efficient in prevention and treatment of hand-foot syndrome caused by Capecitabine.The second part is a clinical research.Objective:To investigate the effect of the external treatment of Tongluo powers in hand-foot syndrome caused by Capecitabine. Methods:35 patients with hand-foot syndrome,which were caused by chemotherapy drug Capecitabine.All the patients washed and soaked the diseased regions by Tongluo powers,20 minutes every time,twice daily,7 days as a cycle.Results:35 patients were studied,33 patients showed very good response,The effective rate and significant effective rate were 94.29%(33/35)and 45.71%(16/35),29 patients with pain were studied,27 patients relieved the pain.The remissive rate and significant remission of pain were 93.10%(27/29)and 55.17%(22/29).The average time from therapy beginning to pain relieves was 1.93±0.92 days.Conclusion:The external use of Tongluo powers could treat hand-foot syndrome caused by Capecitabine,which is worthy of a further research and promotion in oncological clinic.