Analysis Of Extrapulmonary Manifestations Of Mycoplasma Pneumoniae Pneumonia In Children

ObjectiveTo analyze the incidence of extrapulmonary manifestations associated with Mycoplasma pneumoniae pneumonia in children,and to explore the risk factors,so as to provide a basis for early identification,prevention and treatment of extrapulmonary manifestations.MethodsThe object of the study are 208 cases of Mycoplasma pneumoniae pneumonia(MPP)patients hospitalized in the second hospital of Jilin University in December 2015 to November 2016,the incidence of extrapulmonary manifestations of each system was calculated.The object were divided into 2 groups according to concomitant extrapulmonary manifestations,to analysis of the effect of gender,age,clinical characteristics,early application of macrolide antibiotics,CRP and fever period for MPP children to have extrapulmonary manifestations.ResultsExtrapulmonary manifestations associated with MPP involving almost all body systems,there were 85 cases with extrapulmonarymanifestations and 123 cases showed no extrapulmonary manifestation,the incidence of extrapulmonary manifestations is 40.86%.There were38 cases(18.27%)of digestive organ manifestations,30 cases(14.42%)of cardiovascular system manifestations,16 cases(7.69%)urogenital tract manifestations,15 cases(7.21%)of dermatological manifestations,6cases(2.88%)of neurological manifestations,3 cases(1.44%)of hematological/hematopoietic system manifestations,1 cases(0.48%)of musculoskeletal system manifestations and 3 cases(1.44%)of other manifestations.208 patients were divided into 2 groups,85 cases with extrapulmonary manifestations,123 cases with no extrapulmonary manifestations(control group).The gender,age,fever period differences of the two groups were not statistically significant(p>0.05).Compared with the control group,the experimental group was more likely to have lung shadow,higher level of CRP and longer time(days)from the onset to the application of macrolide drugs(p <0.05).Logistic regression analysis showed that imaging examination revealed large shadow of lung(OR= 3.311,95%CI:1.468-7.470),higher level of CRP(OR=1.086,95%CI:1.051-1.123)and longer time(days)from the onset to the application of macrolide drugs(OR=1.726,95%CI:1.412-2.110)were independent risk factors for MPP children to have extrapulmonary manifestations(p <0.05).Conclusions1.Extrapulmonary manifestations associated with MPP involving almost all body systems.2.MPP patients with higher CRP and imaging examination revealed large shadow of lung were more likely to have extrapulmonary manifestations.3.From the onset to the use of macrolide drugs for a long time is a risk factor for MPP patients with extrapulmonary manifestations,suggesting that the early use of macrolides may reduce the occurrence of extrapulmonary manifestations.