Study On The Correlation Between Serum Uric Acid Level And Mild Cognitive Dysfunction In Newly Diagnosed Parkinson 's Disease

Objective To investigate the correlation between serum uric acid(UA)levels and mild cognitive dysfunction in newly diagnosed patients with Parkinson's disease(PD).Methods 1.80 patients with PD(43 males and 37 females)who were treated for the first time in our neurological clinic and who did not undergo any anti-PD treatment were selected as the observation group,the above patients underwent Hoehn-Yahr stage(H-Y stage)? 3.0 and had no clinical manifestations of dementia.A total of 70 individuals(35 males and 35 females)who were admitted to our hospital at random were selected as control group.2.The levels of UA and creatinine(SCr)in the morning fasting blood of the observation group and the control group were measured.3.Patients in the observation group were divided into early PD group and PD middle group according to H-Y stage.Among them,there were 46 patients in the early PD group,including 24 males and 22 females;there were 34 patients in the PD middle group,including 19 males and 15 females.4.PD patients were divided into two groups: no cognitive dysfunction group(PD-NCI group)and PD-MCI group,according to Parkinson's disease with mild cognitive impairment(PD-MCI)diagnostic criteria.Among them,there were 48 patients in the PD-NCI group,including 26 males and 22 females;there were 32 patients in the PD-MCI group,including 17 males and 15 females.5.All statistical analyzes were performed using SPSS version 17.0.Results 1.Comparison of general clinical data: The difference was not statistically significant(P>0.05)between the observation group and the control group: age,female ratio,educational years,SCr and body mass index(BMI);the difference was statistically significant(P<0.05)between the observation group and the control group: Blood UA,Mo CA values.2.There was no significant difference in the SCr concentration between PD-NCI group,PD-MCI group and control group(P>0.05);the concentration of UA in the PD-NCI group and PD-MCI group was lower than that in the control group,the concentration of UA in PD-MCI group was lower than that in PD-NCI group.The above differences were statistically significant(P<0.05).3.The concentration of UA in PD-NCI group and PD-MCI group was lower than that in the control group for female individuals,the concentration of UA in PD-MCI group was lower than that in PD-NCI group for female individuals,the above differences were statistically significant(P<0.05);the concentration of UA in PD-NCI group and PD-MCI group was lower than that in the control group for male individuals,the concentration of UA in PD-MCI group was lower than that in PD-NCI group for male individuals,the above differences were statistically significant(P<0.05);when UA concentrations were compared between men and women in each group,the difference was not statistically significant(P>0.05).4.For PD-MCI patients: The Mo CA score in the early and middle groups was lower than that in the control group,the Mo CA score in the early group was higher than that in the middle group,the above differences were statistically significant(P<0.05);UA concentration in the early and middle groups was lower than that in the control group,the above differences were statistically significant(P<0.05);when UA concentrations were compared between the early group and the middle group,the difference was not statistically significant(P>0.05).5.For PD-NCI patients: The Mo CA score in the early and middle groups was lower than that in the control group,the Mo CA score in the early group was higher than that in the middle group,the above differences were statistically significant(P<0.05);UA concentration in the early and middle groups was lower than that in the control group,the above differences were statistically significant(P<0.05);when UA concentrations were compared between the early group and the middle group,the difference was not statistically significant(P>0.05).6.There was a positive correlation between the concentration of UA and the naming ability of Mo CA in PD patients,and there was not a significant correlation with other cognitive fields.Conclusions 1.PD patients have lower blood UA level than healthy individuals,the level of UA in PD patients with mild cognitive impairment will be further reduced,this conclusion applies to both men and women.2.For non-dementia patients with PD,the degree of cognitive in the early PD group is lower than the PD middle group,blood UA level is lower than healthy individuals,but there is no significant difference about blood UA levels in patients with different stages.3.There is a positive correlation between the blood UA level and the naming ability of Mo CA in PD patients,and there is no significant correlation with other cognitive fields.4.The decrease of UA concentration may be one of the mechanisms for the occurrence of PD and the decline of cognitive function.