Correlation Study Between Mild Cognitive Impairment And Associated Risk Factors In Parkinson's Disease

Objective: Parkinson's disease mild cognitive impairment(PD-MCI)is one of the common non-motor symptoms of PD,which has a certain degree of reversibility.In this study,we discussed the risk factors related to PD,so as to optimize the management of PD patients.Methods:1.Patients who met UK Parkinson's Society Brain Bank Diagnostic Criteria were used as the experimental group(PD group),the control group was the Parkinsonian syndrome group(PDS group)and the healthy control group.According to the cognitive function,PD group and PDS group were respectively subdivided into PD-MCI group and PD normal cognitive group,PDS-MCI group and PDS normal cognitive group.2.We collected general data(such as age and gender)and blood samples to detect the levels of blood lipids(TC,TG,HDL,LDL),TBIL,DBIL,IBIL,UA,HCY.The PD group and PDS group were evaluated by Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA),the mini-mental state examination(MMSE)and Montreal cognitive assessment(Mo CA).The PD group was assessed according to unified Parkinson's disease rating scale-III(UPDRS-III)motor assessment and Hoehn-Yahr stage(H-Y stage).Results: HAMD scores,HAMA scores,UPDRS-III scores and H-Y stages in PD-MCI group were significantly higher than that of PD normal cognitive group(P<0.05).The levels of TC,TG,HDL,LDL and UA in PD group were significantly lower than those in the healthy control group,while DBIL and HCY were significantly higher than those in the healthy control group.The levels of TC,TG,HDL,LDL,IBIL and UA in PD-MCI group were lower than those in the healthy control group,while DBIL and HCY were significantly higher than those in the healthy control group(P<0.05).There was no statistical significance in serology markers between the PD-MCI group and PD normal cognitive group.The levels of TC,TG,HDL,LDL,TBIL,IBIL,UA(among male patients)in PDS group were lower than those in the healthy control group.The levels of TC,TG,HDL,LDL,TBIL,IBIL,UA(among male patients)in PDS-MCI group were lower than those in the healthy control group(P<0.05).PD-MCI was associated with hypertension history,HAMD scores,HAMA scores,UPDRS-III scores and H-Y stages.There was significant difference between UPDRS-III scores and PD-MCI in Logistic regression analysis(P<0.05).Conclusions:1.Mild cognitive impairment is more likely to occur in PD patients with hypertension history,severe motor symptoms and conditions,maybe accompanied by anxiety and depression.UPDRS-III score is an independent risk factor for PD-MCI.2.Patients with PD,PD-MCI and patients with PDS,PDS-MCI have abnormal lipids,bilirubin,uric acid,and HCY.