| Objective: To detect and discuss the associations of gender,age,years of schooling,height,weight,BMI,SBP,DBP,smoking status,drinking status,FBG,TG,CH,LDL-CH,HDL-CH,and Hs-CRP with the prevalence of VMCI in CSVD patients,and find out independent risk factors.Method: 300 CSVD patients were divided into two groups according to the VMCI status diagnosed by Mo CA scores.Therefore,162 patients were assigned to the non-VMCI group while 138 were assigned to the VMCI group.Gender,age,years of schooling,height,weight,BMI,SBP,DBP,smoking status,drinking status,FBG,TG,CH,LDL-CH,HDL-CH,and Hs-CRP of all participants were collected by professional practitioners.All tested indexes of the two groups were statistically analyzed;independent risk factors were detected by taking stepwise regression analysis and ordinal Logistic regression analysis.Result: Single variant regression found the growth of age,FBG,SBP,CH,TG,LDL-CH,hypertension,and dyslipidemia were risk factors for decrease of Mo CA score.Single variant Logistic regression found that increase of age,CH,LDL-CH,hypertension,and dyslipidemia were risk factors for VMCI.The outcome of the stepwise regression analysis demonstrated that growth of age,LDL-CH,and hypertension were the only three independent relevant factors for the decline of the Mo CA scores.The R square of this model reached0.69;among which,every 1 year increased average age related to 1.74 decreased Mo CA score,every 1 mmol/L increased average LDL-CH related to1.61 decreased Mo CA score,and patients with hypertension had average 1.34 decreased Mo CA score.The result of the ordinal Logistic regression analysis demonstrated that growth of age,LDL-CH,and hypertension were the only three independent risk factors of VMCI for CSVD patients.Of which,every 1 year increased average age would raise the risk of VMCI with 26% for CSVD patients,every 1 mmol/L increased average LDL-CH would raise the risk of VMCI with 44% for CSVD patients,and CSVD patients with hypertension would have 100% of raised risk to get VMCI.Conclusion: Growth of age,LDL-CH,and hypertension were the three independent relevant factors for the decline of the Mo CA scores as well as the risk factors of VMCI for CSVD patients.Objective: To study the diagnostic value of the MoCA scores and the radiological features for VMCI in CSVD patients.Method: 300 CSVD patients were divided into two groups according to the MCI status diagnosed by Mo CA scores.Therefore,162 patients were assigned to the non-VMCI group while 138 were assigned to the VMCI group.Gender,age,years of schooling,height,weight,BMI,SBP,DBP,smoking status,drinking status,FBG,TG,CH,LDL-CH,HDL-CH,and Hs-CRP of all participants were collected by professional practitioners.Radiological data were collected by taking skull MRI scanning.Infarcts at frontal area,thalamus area,temporal area,basal ganglia area,and Infratentorial area of the both sides were counted and recorded.Lesion of WML were counted and graded with Fazekas evaluation system.CMBs lesions at lobe and deep brain tissue were separately counted.EPVS lesions at basal ganglia area,white matter area,and hippocampus area were counted and graded,respectively.All tested indexes of the two groups were statistically analyzed;radiological data of the four types of CSVD lesions were compared between the two groups too.Result: There were 300 participants in total,including 162 in the non-VMCI group(93 males vs 69 females,with the average age of 62.84±5.11)and 138 in the VMCI group(71 males vs 63 females,with the average age of 64.17±5.59).Inter-group analysis showed significant higher age,BMI,SBP,serum CH,TG,LDL-CH,and Hs-CRP levels.Categorical data were analyzed with Chi-square test and it demonstrated significant higher prevalence of hypertension and dyslipidemia for the VMCI group.MRI scanning diagnosed 108 patients of VMCI group and 42 of non-VMCI group with LI lesions on different areas.Lesions on all the five interested areas for the VMCI group was significantly more than the non-VMCI group.In the VMCI group,patients with multiple lesions accounted for 34.8%(48)while those with single lesion accounted for 43.5%(60);and in the non-VMCI group,no patients had multiple lesions while those with single lesion accounted for 25.9%(25).Diagnostic results showed 37.6% patients in the non-VMCI group and94.2% in the VMCI group were taking WML lesions.Results of the Chi-square test demonstrated that the VMCI risk for CSVD patients was significantly associated with Fazekas grades.Linear regression outcomes showed that with the growth of the Fazekas grades,Mo CA scores were significantly decreased.It also displayed 16.0% patients in the non-VMCI group and 43.5% in the VMCI group were carrying CMBs lesions.Of which,12(7.4%)patients in the non-VMCI group were carrying CMBs lesions only at the deep brain tissue,and14(8.6%)were carrying lesions at the lobe.While for patients in the VMCI group,9(6.5%)were carrying lesions at the deep brain tissue only,25(18.1%)were carrying lesions at the lobe only,and 26(18.8%)were carrying lesions at the both sites.268(89.3%)patients had different levels of EPVS lesions.In the non-VMCI group,45.1%(73)were of the level 1,35.2%(57)were of the level 2,and no patients with higher levels.In the VMCI group,4.3%(6)were of the level 1,15.9%(2)were of the level 2,43.5%(60)were of the level 3,35.2%(50)were of the level 4.Outcome of the CMS test demonstrated that the two groups had significant difference of the EPVS grades at all detected areas(all P<0.0001).Conclusion: The non-VMCI group showed significantly higher total score and the subgroup scores for all the items of Mo CA.MRI scanning showed significant more lesions of LI,WML,CMBs and EPVS for patients of the VMCI group compared with those of the non-VMCI group.Among which,patients in the VMCI group had significant higher prevalence of multiple LI lesion,Fazekas grades,prevalence of mixed CMBs sites,and EPVS grades at different areas compared with patients in the non-VMCI group.Objective: To investigate the associations of serum Hcy and blood UA levels with VMCI in patients with CSVD.Methods:A total of 172 CSVD cases who received treatments between June2013 to July 2015 were selected from our hospital and randomly divided into the vascular mild cognitive impairment(VMCI)group and non-VMCI group.another86 cases were from physical examination center as control group.the Pearson method was applied to detect the relevance of Hcy and BUA levels with the clinical data for VMCI patients.The correlation of Hcy and BUA levels with Mo CA total score and the correlation of VMCI with its related factors were analyzed.Results: The folic acid and VitB12 levels were lower in VMCI group than that in non-VMCI group and control group,but the Hcy and BUA levels were higher than that in non-VMCI group and the control group(all P< 0.05).Compared with the control group,non-VMCI group had lower folic acid and Vit B12 levels and higher Hcy and BUA levels(all P< 0.05).Both Hcy and BUA had predictive effects on VMCI,the sensitivities of which were 71.70% and 68.50%,and the specificities of which were 61.20% and 91.20% respectively.The BUA and Hcy levels were negatively correlated with folic acid,Vit B12,Mo CA score,visual space and implementation capacity,attention and calculation ability,language,delayed recall and subscale scores,but were in positive association with cholesterol(CH)(all P< 0.05).VMCI of CSVD were negatively correlated with folic acid and Vit B12,but was positively associated with Hcy and BUA(all P<0.05).Conclusion: Serum Hcy and BUA levels were positively correlated with VMCI of CSVD,and both had relatively predictive effects on VMCI. |
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