The Epidemiological Association Study Of Serum Uric Acid And Parkinson’s Disease With Cognitive Impairment

Part 1 Serum uric acid levels and the risk of Parkinson’s disease Objective:In recent years,more and more studies have found that the level of serum uric acid in patients with Parkinson’s disease(PD)is significantly lower than that in healthy people.Some prospective cohort studies have found that serum uric acid levels are associated with the risk and progress of Parkinson’s disease.But most of the study subjects are European and American people,and there are few prospective studies on Chinese or Asian populations.Therefore,the main purpose of this study is to explore the association between serum uric acid and the risk of Parkinson’s disease in Chinese people.Methods:We conducted a population-based cohort study(the follow-up cohort of elderly people over 50 years in Malu County Jiading District,Shanghai)to investigate the newly diagnosed patients with Parkinson’s disease from 2011 to the end of 2017.Then we analyze the association between hyperuricemia and the incidence of PD by Cox regression and Logistic regression.Results: The Cox regression analysis showed that there was no significant association between hyperuricemia and the incidence of PD(HR =3.162,95%CI:0.872 ~11.464,p =0.080).The Logistic regression results also showed that the incidence of PD in patients with hyperuricemia was no statistical difference compared with the non-hyperuricemia group(OR =4.173,95%CI:0.873 ~19.939,p =0.073)after adjusting for the age,gender and other confounding factors.Conclusion: There was no significant association between hyperuricemia and the incidence of PD in this cohort study based on the community in Malu.Part 2 Serum uric acid levels and association with cognitive impairment Objective:The association between serum uric acid and cognitive impairment/dementia has always been a topic of debate over the past 10 years,the relationship remains elusive today.Several studies have found that higher serum uric acid level can delay the occurrence of cognitive impairment and dementia,but some other studies also considered that higher serum uric acid can promote the occurrence of cognitive impairment.Therefore,the main purpose of this study is to explore the association between serum uric acid and cognitive impairment in Chinese people.Methods:We collated the data of MMSE scores in every follow-up from May 2011 to August 2016,based on a population-based cohort study(the follow-up cohort of elderly people over 50 years in Malu County Jiading District,Shanghai).Then we analyze the association between serum uric acid and the incidence of cognitive impairment by Logistic regression,and explore the association between serum uric acid and cognitive decline rate by linear regression Results: Logistic regression analysis showed that higher serum uric acid had no significant protective effect on the incidence of cognitive impairment.However,linear regression analysis showed that the level of serum uric acid may be associated with the rate of cognitive decline.The higher uric acid level maybe a protective factor for cognitive decline in younger elderly(β=0.203,95%CI: 0.0602 ~0.346),but the relationship is no longer significant among middle aged and elderly people.Conclusions: No significant correlation was found between hyperuricemia and the incidence of cognitive impairment in this cohort study.However,the difference of baseline serum uric acid level will affect the cognitive function decline rate in the future.