Effects Of Daily Dose Of Levodopa And Oxidative Stress Injury On Mild Cognitive Impairment In Parkinson’s Disease

Objective: To investigate the effects of white blood cell(WBC),hemoglobin(HGB),uric acid(UA),homocysteine(Hcy)and lipoprotein a(Lpa)related oxidative stress injury and daily dose of levodopa(LEDD)on mild cognitive impairment in Parkinson’s disease(PD-MCI).Methods: Patients with Parkinson’s disease(PD)who attended the First Hospital of Handan from September 2017 to October 2019 were collected.Using Mini-mental State Examination(MMSE)and the Unified parkinson’s disease rating scale(UPDRS)Part III and Hoehn-Yahr staging to evaluate patients,choose Hoehn-Yahr stage 2.0 or less and exclusion of patients with Parkinson’s disease dementia(PDD).According to the results of the Montreal cognitive assessment scale(MoCA)score,PD patients included in the study were divided into two groups: mild cognitive impairment with Parkinson’s disease(PD-MCI)group and Parkinson’s disease with no cognitive impairment(PD-NCI)group.Fasting blood was drawn for blood WBC,HGB,UA,Hcy and Lpa levels.The types and doses of oral medications in PD patients were collected and converted to daily dose of levodopa(LEDD).Results: A total of 57 PD patients were included in this study,including 37 in the PD-MCI group and 20 in the PD-NCI group.1.There were more male patients than female patients in PD-MCI group and PD-NCI group.There was no significant difference in the composition ratio(P> 0.05),and there was no significant difference in age,course of disease and education level between the two groups.(P> 0.05).2.There was no significant difference in blood WBC and Lpa levels between PD-MCI group and PD-NCI group(P> 0.05).The differences in HGB,UA and Hcy levels were statistically significant(P <0.05).3.There was no significant difference in LEDD level between PD-MCI group and PD-NCI group(P> 0.05).4.The levels of HGB,UA,and Hcy in the PD-MCI group were correlated with the scores of the MoCA scale(P <0.05).The scores of HGB and the MoCA scale were positively correlated(R = 0.402).The blood UA levels and MoCA The scale score had apositive correlation(R = 0.6),and the blood Hcy level had a negative correlation with the MoCA scale score(R = 0.754).Conclusions:1.LEDD level has no effect on cognitive dysfunction in PD patients.2.The blood HGB level of PD-MCI patients is lower than that of PD-NCI patients.The blood HGB level is positively correlated with the MoCA scale score.3.The level of blood UA in patients with PD-MCI is lower than that in patients with PD-NCI.There is a positive correlation between the level of blood UA and the score of MoCA scale.4.The level of blood Hcy in PD-MCI patients is higher than that in PD-NCI patients.The level of blood Hcy is negatively correlated with the score of MoCA scale.5.HGB,UA,Hcy related oxidative stress damage has an impact on PD-MCI,which may be the pathogenesis of PD-MCI,HGB,UA is a protective factor for PD-MCI,and high Hcy is a risk factor for PD-MCI.