| Objective According to the survey of the clinically relevant data and traditional chinese medicine constitution for rosacea,the study was aimed to describe the clinical characteristic of rosacea,then explore associated risk factors of rosacea and discuss the traditional chinese medicine etiology and pathogenesis of rosacea based on chinese medicine constitution,finally provide clinical evidence and new ideas for individualized prevention and treatment of rosacea ?Methods Based on the unite domestic and foreign standardization scale of risk factor questionnaire,?Rosacea Risk Factors Epidemiological Questionnaire ? was established.Rosacea patients from outpatients at dermatology department of the first hospital of wuhan were included from May 2015 to March 2016.The general state of health,life behavior,eating habit,family history,associated risk factors and other basic information were collected.The inspection report 0f demodex folliculorum were checked out by CT checkout room teachers and HP check test were collected.Under the guidance of the standardized constitution in Chinese medicine questionnaires,with the help of professional dermatologist,relevant medical history and physique were evaluated.Eventually,all the dates should be entered in SPSS19.0 statistical software to make statistical analysis of pathogenic factors and distribution characteristic in Chinese medicine constitution after collecting all the cases.Results 1.142 rosacea patients were enrolled for this study at department of dermatology.The age range from 15 years to 67 years,The average age is 29.63 ±8.77 years.Female who diagnoses rosacea age was focused on 36-45 years and the number was 4.5 times than male,the main type was Erythmatotelangiectatic rosacea.2.The morbidity age was range from 15-47 years,80.28% of patients had a history of facial flushing.3.The main clinical manifestations of rosacea were erythema,telangiectasias,papules and pustules on the cheeks(89.43%),nose(65.49%),perioral and mandibular(61.27%),Zygomaticus(57.04%),forehead(47.89%),lower jaw(13.38%),ears(4.93%),neck(4.23%),periorbital(2.11%).Nearly 85.80% patients may feel uneasy.Rosacea can also be associated with symptoms of burning,redness,itching or swelling.3.Risk factors: Rosacea follows a course of exacerbations and remissions and is often aggravated by envirnmental factors,Emotional factors,Ultraviolet rays and so on.Among all the following factors,risk ratio decreased in proper order(high temperature87.32%,burning sunshine 76.76%,sentiment changes 60.56%,hot and spicy food 40.14%,season27.46% and wine9.15%),three patients considered before menstruation rash worse.4.Demodex folliculorum infection has been found in all the rosacea patients.But it was nearly no relationship with sex,age and skin type,course of diseases and symptoms.A significant statistical differences has been found in the characteristic of skin.The number of demodex folliculorum in the oil skin was 6.91 ±3.06 and was easily found.Demodex folliculorum infected density and the number of individual hair follicles are significant differences between the infected skin lesions and non-skin lesions.Demodex folliculorum density at the infected skin lesions higher than non-skin lesions,and the infected skin lesions of erythematotelangiectatic rosacea has a lower infected density(25.07±12.54%)than papulopustular rosacea(43.84± 20.09%).The rate of helicobacter pylori infection is 59.26%.5.Chinese medicine constitution classification analysis :Totally 441 cases were collected,besides 3 cases of typical constitution type,the other were mixed constitution.Among them,yin-deficiency constitution amount to 96 cases,accounting for 21.7%,qi-depressed constitution amount to 77 cases,accounting for 17.46%,damp-heat constitution amount to 76 cases,accounting for 17.23%,qi-deficiency constitution amount to 74 cases,accounting for 16.78%,phlegm-dampness constitution amount to 41 cases,accounting for 9.39%,yang-deficiency constitution amount to 36 cases,accounting for 7.48%,blood-stasis constitution amount to 33 cases,accounting for 7.48% and gentleness constitution amount to 3cases,accounting for 0.08%.Besides,Among the yin-deficiency physique,Erythmatotelangiectatic rosacea takes up 75%,and papulopustular rosacea occurred takes up 55.41% in hot-dampness physique.Yin-deficiency physique patients with risk factors were high temperature,sentiment changes,burning sunshine.Qi-depressed constitution patients with risk factors were burning sunshine,sentiment changes,high temperature.Damp-heat constitution patients with risk factors were hot and spicy food,high temperature,sentiment changes.Conclusion 1.Mid-age(36-45 years)female accounts for the majority of rosacea.The majority of rosacea patients have a history of facial flushing,often accompanied by facial burning,itching,tight discomfort.2.Even the pathogenesis of rosacea remains unknown,temperature changes,psychological factors,hot and spicy food and burning sun have all been implicated.Heat,sun,mood changes is the incidence of rosacea or aggravating factors.Demodex folliculorum infection,spicy and hot food,alcohol relate very closely to the development of rosacea.The effection of Helicobacter pylori infection in rosacea is not entirely clear.3.Mixed constitution is widespread among the majority of the rosacea,yin-deficiency followed,phlegm-dampness constituTion,qi-depressed constitution,damp-heat constitution,yangdeficiency constitution,qi-deficiency constitution,blood-stasis constitution and normal constitution at last.4.There are differences between different clinical features and risk factors in rosacea patients with different physique.Patients with Erythmatotelangiectatic rosacea occurred in relatively yin-deficiency physique,and papulopustular rosacea occurred in relatively hot-dampness physique. |
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