Clinical Observation On The "Fu Zheng Hua Yu" Method Combined With Moxibustion And Effect On Tumor Necrosis Factor-α

Purpose:Comparing the changes of pelvic pain,signs,Tumor necrosis factor-a (TNF-α),CA125,B-Ultrasonic in endometriosis patients before and after treatment, by observing clinical efficacy of Fuzhenghuayu method combined with Moxibustion treatment in 45 cases with kidney deficiency and blood stasis type of pelvic pain of endometriosis. Evaluation clinical efficacy of the method treatment pelvic endometriosis, observe the effects of TNF-a, and to explore mechanism of the method. Open up new therapeutic approaches to Chinese medicine for the treatment of endometriosis.Method:By collecting 45 cases which were treated in our hospital and met the inclusion criteria of the kidney deficiency and blood stasis type of pelvic pain of endometriosis, randomly divided this cases into 3 groups:treatment group of 15 patients treated with Fuzhenghuayu method combined with Moxibustion; control group A group included 15 patients with Fuzhenghuayu method; control group B group contained 15 patients with moxibustion before and in the menstrual period. To compare the changes of related symptoms,signs,TNF-α,CA125,B-Ultrasonic and etc before and after treatment.Result:Before and after treatment, pain score. NRS score, clinical symptoms and signs scores were followed respectively:treatment group(12.57±2.17),(5.87±1.6),(17.07±5.55),(6.07±2.4) and (6.10±0.28),(1.77±0.60),(3.87±2.33),(3.27±1.35); control group A group(11.77±1.27),(5.53±1.06),(15.47±2.77),(5.8±1.15) and (6.90±0.55),(2.33±0.49),(7.47±2.56),(3.53±0.92); control group B group(11.60±1.03),(5.27±0.88),(14.13±2.67),(5.13±1.30) and (7.3±0.75),(2.80±0.68),(9.47±2.45),(4.53±0.99). Compared treatment group and control group pain scores, NRS score, clinical symptoms scores, all P<0.05; compared three groups of signs, treatment group and control group B group P<0.05, but treatment group and control group A, or control group A and B, P>0.05. After treatment, the overall level of CA125 and TNF-αwas less than its than before treatment. Treatment group have 9 cases in markedly, its effective rate was 64%, and the total effective rate was 86%; control group A group have 6 cases in markedly,5 cases in effective,and the total effective rate was 71%; control group B group have 2 cases in markedly,7 cases in effective,and the total effective rate was 60%.Conclusion:Fuzhenghuayu method combined with Moxibustion treatmenting pelvic pain of endometriosis can achieve the effect of relieving pain and improving the symptoms and signs, The therapeutic effect of treatment group is better than control group with only a simple method. After treatment, the overall level of CA125 in three groups were decreased, the effect in treatment group is obviously better than control group; the level of TNF-a in three groups significantly were decreased, the effect in treatment group is better than control group. All three groups can be by reducing the level of TNF-a expression, so as to achieve the effect of pain relief.