| Objective: Observation of Yitongxiao clinical efficacy on painwhich was caused by dampness and blood stasis type endometriosis,reveals the effect mechanism, for Yitongxiao in treatingendometriosis pelvic cavity pain and provide a theoreticalbasis. analysis the composition characteristics and provide newtreatment of traditional Chinese medicine prescriptions of clinicaltreatment endometriosis.Methods:181standard cases were divided into three groups:experimental group (90patients) were treated withYitongxiao;chinese medicine control group(60patients) were treatedwith Sanjie Zhentong capsule; western medicine control group(31patients) were treated with Fenbid, all groups were treated for threemonths. Clinical symptom improvement, scores of dysmenorrhea, andTXB2,6-Keto-PGF1α,β-EP,CA125in plasma were all observed before andafter the treatment. The data getted were then established into a newdatabase and analysised by SPSS17.0.Results: Relieving endometriosis pelvic pain,statistically, the experimental group was superior to chinesemedicine control group but there was no statisticalsignificance(P>0.05), significantly better than the westernmedicine control group and there were significantdifference (P<0.01). Improvement of endometriosis symptomsof traditional Chinese medicine curative effect inexperimental group, chinese medicine control group, westernmedicine control group total effective rate were97.14%,91.43%,34.29%. Statistically, the experimental groupwas superior to chinese medicine control group but notstatistically significant, was better than that of Western medicine control group and there were significant difference(P<0.01). Remission of Endometriosis Dysmenorrhea effect ofexperimental group, chinese medicine control group, westernmedicine control group total effective rate were92.38%,75.71%,37.14%. Statistically, the experimental groupwas superior to chinese medicine control group but notstatistically significant, was better than that of Westernmedicine control group and there were significant difference(P<0.01). Dysmenorrhea scores, the experimental group thanchinese medicine control group decreased significantly butthere was no statistical significance (P>0.05), decreasedsignificantly better than western medicine control group andthere was significant difference (P<0.01). Results oflaboratory tests, the experimental group can reduce the TXB2,CA125levels, and were reduced significantly compared toChinese medicine the control group, but no statisticalsignificance (P>0.05), decreased significantly better thanwestern medicine control group and there was significantdifference (P<0.01). The experimental groups can increase6-Keto-PGF1αlevel and adjust the balance, and compared to theChinese medicine control group increased obviously but withno statistical significance (P>0.05). The extent of theincrease was significantly better than the western medicinecontrol group and there were significant difference(P<0.01). The experimental groups can increaseβ-EP levels,and Chinese medicine control group increased obviously butwith no statistical significance (P>0.05), the extent ofthe increase was significantly better than the westernmedicine control group and there were significant difference(P<0.01). Conclusions: Yitongxiao had exactly safe and non-side reactiveclinical curative effection in treatment of dysmenorrhea which wascaused by dampness and blood stasis type endometriosis.TCM had betterlong-term curative effect in dysmenorrhea remission that reflectedTCM's feature and advantage. |
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