Clinical Investigation Of Vesicle Formatin In Oral Submucous Fibrosis

Objective(1)To explore the incidence of the formation of vesicle, and to analyze the association of vesicle formation and the age,sex, hobbies of smoking and drinking,as well as the mouth opening.(2)To observe and analyze the clinical features,the pathogenesis and progression of vesicle of patients with oral submucous fibrosis.Methods Two hundreds and sixty four patients with oral submucous fibrosis who were treated in the Department of Stomatology, Scecond Xiangya Hospital of Central South University between Sep 2004 and Apr 2008,were investigated as sample(1)with clinical infoumatin, including the age,sex,hobbies of smoking and drinking,the mouth opening,the vesicle formation.Twenty nine patints with oral submucous fibrosis and vesicle formation concurrently who were treated in the Department of Stomatology,Scecond Xiangya Hospital of Central South University between Sep 2006 and Oct 2006,were investigated as sample(2)with clinical features,including the quantity,size,shape,region to break out frequently,diaphaneity,and ulcer concurrently,according to a self-designed new zoning method for the palate.Frequencies statistics was performed for all the results of sample(1)and sample(2),and Chi-square test was performed for vesicle formation and the age,sex, hobbies of smoking and drinking,the mouth opening.Results(1)The incidence of formation of vesicle of sample(1)was 26.5%, and the incidence of the patients who had once had vesicle but didn't have on clinical examination was 17.8%.The incidence of all the patients who have already had vesicle was 44.3%. (2)The results of Chi-square test were P＜0.05,therefore vesicle formation has no concern with the age,sex,hobbies of smoking and drinking,the mouth opening.(3)The mean of the quantity of vesicle formation of sample(2)was 6.2,the maximum was 19,and the minimum was 1.Three grades were made by the quantity:＜5,5-15,＞15,and the rate were 58.6%,31.0%, 10.3%respectively.Three grades for size were made by diameter of vesicle:1-2mm,2-4mm,＞4mm,and the rate were 48.3%,37.9%, 13.8%respectively.There are 7 cases which have vesicle and uncle concurrently.All the vesicle of patients was transparent and circular except two case were oval and irregular.Vesicle predominated in the center of the soft palate,and decrease gradually around.Conclusion(1)Vesicle formation is a common clinical symptom and sign,and it should be received considerable attention.(2)Vesicle predominated in the center of the soft palate,and decrease gradually around.The quanity of vesicle in multitudinous cases were less than five,and the size was less than 4mm.Most of the vesicle was transparent and circular,and some cases had uncle concurrently.(3)Vesicle formation has no concern with the age,sex,hobbies of smoking and drinking,the mouth opening.It might be an independent clinical sign of oral submucous fibrosis.