| Premenstrual Syndrome (abbreviation for PMS) is the syndrome of repeatedly appearance of spirit,behavior and somaplasm abnormality, which happens among reproductive women seven to fourteen days before menstruation and disappears after menstrual onset or run-out.ObjectiveIn this study, we try to gain the message of Chinese Medicine Syndrome distribution rule of the PMS patients with excess syndrome, and evaluate the relationship between patients'personality characteristics and premenstrual syndrome, hoping to establish standard evaluation system of clinical research for prevention and therapy for PMS of Chinese Medicine and provide with strict scientific informationMethodsThe study used the research methods of epidemiology, adapted synchronization observation and analysis of multi-subjects and the investigation projects includes two parts, namely Chinese Medicine symptom questionnaire and Eysenck Personality Inventory. Our criteria standardization used diagnosis standardization of integrated medicine of Chinese medicine and Western medicine, referring to new century textbook of gynecology in Chinese Medicine,diagnosis and treatment standardization of diseases and symptoms in Chinese Medicine, and the sixth edition obstetrics and gynecology, etc. In the research, we recruited 502 cases with PMS deficient syndrome. Survey of Chinese Medicine syndrome includes symptoms before menstruation and symptoms collected by Chinese four diagnositic methods, totally forty-three items. There is spargosis,chest distress,restlessness and easy tantrum headache,insomnia,distending pain of lower abdomen bad appetite,dizziness,hypochondriac pain,depression,easy sighing,absence of mind,delayed menorrhea, dryness of mouth and pharynx,fatigue,low emotion,constipation,upset,softness and weakness of waist and knee,edema, dryness of eyes,tidal fever,ructation,feverish sensation over the palm and sole,loose stool,diarrhea caused by emotion,gastric distention,general malaise,proceeded menorrhea,bullimia,yellow urine,dental ulcer,bitter taste of mouth,flushing,red eye,night sweat,rugitus and flatus,tinitus,facial drying and heating,fear,non-traumatic hemorrhage,tongue manifestation,pulse manifestation. Adult revised edition of Eysenck Personality Questionnaire (abbreviation for EPQ) used in China, which include totally 88 items, was applied to investigate cases'Personality characteristic. Distribution of Chinese Medicine symptoms was analyzed by descriptive statistics. Through observing their frequency, we tried to explore the distribution information of major Chinese Medicine symptoms,tongue manifestation and pulse of PMS. Cluster analysis was used to classify the investigation crowd in order to observe the distribution of Chinese Medicine syndrome information, and make concordance analysis between results of cluster analysis and classify results of Chinese Medicine syndrome diagnosed clinically. Based on clinical experience and literature research, we used the severity of spargosis,chest distress,distending pain of lower abdomen,headache,restlessness and easy tantrum, dizziness,insomnia, bad appetite,easy sighing,depression, hypochondriac pain and edema as evaluation items for PMS. Multiple regression analysis was used to work out the coefficient of regression of total score of PMS and each dimension of P, E,N and L in the Eysenck Personality Inventory. Then regression equation was obtained to explore the quantitative relationship between PMS and personality. Thus patients of each type was divided into one type of the Chinese Medicine's five elements people (wood,fire,earth,metal,water). EpiData software was used to deal with coding data,generating data files,correcting record of data, and transform the database into SPSS database files by its function of shifting out. Then SPSS16.0 was applied to make frequency analysis,cluster analysis and multiple regression analysis.ResultsThere are forty-three items in total on symptoms of female premenstrual and symptoms and signs collected by Chinese four diagnositic methods in the survey. The results showed:common symptoms of our cases occupied the forward ten were spargosis.chest distress.string pulse,restlessness and easy tantrum,headache,insomnia,distending pain of lower abdomen,bad appetite,dizziness and hypochondriac pain. After cluster analysis, cases were classified into five kinds, accounting for about 27.09%.25.70%,19.32%,16.93%.10.96% relatively among all patients investigated, and based on the expertise, their syndrome differentiation was syndrome of upward invasion of liver Qi,syndrome of stagnation of liver-Qi. syndrome of hyperactivity of fire due to yin deficiency,syndrome of liver Qi invading spleen and syndrome of liver fire flaring up. After cluster analysis, concordance between syndrome of upward invasion of liver Qi and clinical diagnosis was 86.76%; concordance between syndrome of stagnation of liver-Qi and clinical diagnosis was 92.25%; concordance between syndrome of hyperactivity of fire due to yin deficiency and clinical diagnosis was 92.78%; concordance between syndrome of liver Qi invading spleen and clinical diagnosis was 95.29%; concordance between syndrome of liver fire flaring up and clinical diagnosis was 65.45%. Incidence of PMS was high, but its symptoms were slight (9.28±3.16分). There were 466 patients under moderate severity, occupying 92.8%. PME was corrective to personality, was negative correlative to Eysenck Personality Questionnaire's dimensions such as psychoticism as P. exterior and inerior E. wrap L, and was positive correlative to neurotic trait as N. ConclusionsFrom investigation results of clinical symptoms in Chinese Medicine, though Chinese symptoms of premenstrual syndrome is very complicate, yet pathological changes of liver are main, dealing with heart,spleen,lung and kidney. Concordance between results of cluster analysis and clinical diagnosis was quite high. Additionally, dimension P. dimension E and dimension L in Eysenck Personality Questionnaire had negative correlation to PMS, while dimension N was positive correlative to PMS, which means the more conservation,quiet,unsociable,lying,lack of sympathy,hatred,excessive emotion and irritable the patients were, the more serious their clinical symptoms were. Scores of P. E and N might have some correlation to Chinese Medicine's five elements people.
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