| Under the current population background of my country’s aging society,the health problems of the elderly urgently require scientific exercise intervention.Based on the Huaxi Artificial Intelligence and Brain Health Management Project,this study uses lower limb resistance training to study the influence of blood factors in the elderly with mild cognitive impairment,and explores an effective training method to prevent and delay mild cognitive impairment method.This study adopts the literature data method,mathematical statistics method and experimental method,and the effect of lower limb resistance training on the blood factors CRP,IL-6 and Irisin in the elderly with mild cognitive impairment is the research object.Through RCT,42 65-75-year-old man with mild cognitive impairment underwent lower limb resistance training for 6 months,and the experimental program adopted progressive load progression.Among them,20 people in the experimental group received lower limb resistance training.The 22 people in the control group received only community health education,and the data before and after the experiment were analyzed using SPSS 27.0 statistical software.Research result:(1)After the intervention,the body weight,SMM,and SMI in the experimental group were significantly higher than those in the control group(p<0.05),and the difference before and after the intervention was significant(p<0.01).There was no difference in BMI between the two groups before and after the intervention(p>0.05),but the difference before and after the intervention was significant(p<0.01).(2)Compared with men,there was a significant difference in SMI between the two groups after the intervention(p<0.01).There was a significant difference in SMI before and after intervention in the experimental group(p<0.01).The differences before and after the intervention were different between the two groups(p<0.01).Compared with women,there was a significant difference in SMI between the two groups after intervention(p<0.01).There was a significant difference in SMI before and after intervention in the experimental group(p<0.01).The differences before and after the intervention were different between the two groups(p<0.01).(3)Comparing the CRP before and after the intervention,there were significant differences between the experimental group and the control group(p<0.01).Compared before and after the intervention,the IL-6 in the experimental group was lower than that before the intervention,with a significant difference(p<0.01),but there was no difference in the control group(p>0.05).Compared with Irisin before and after the intervention,the experimental group was higher than before the intervention,with a significant difference(p<0.01),and there was no difference in the control group(p>0.05).(4)After the intervention,there was a significant positive correlation between Irisin and SMI in the experimental group(p<0.01);there was no correlation between Irisin and SMI in the control group(p>0.05);there was no correlation between Irisin and age in the two groups (p>0.05).(5)After the intervention,the MOCA of the two groups was higher than that before the intervention,and there were significant differences(p<0.01).There was no difference in IADL between the two groups after intervention(p>0.05).Before the intervention,the MMSE of the experimental group was lower than that of the control group,with a significant difference(p<0.01);after the intervention,there was no difference between the two groups(p>0.05).Compared with the MMSE before and after the intervention,there was a significant difference in the experimental group(p<0.01),but there was no difference in the control group(p>0.05).(6)There was no correlation between cognitive function and blood factors in the control group after intervention(p>0.05).There was no correlation between MOCA,IADL and CRP,IL-6,Irisin in the experimental group after intervention(p>0.05).There was a significant negative correlation between MMSE and CRP(p<0.05),no correlation between MMSE and IL-6(p>0.05),and a significant positive correlation between MMSE and Irisin(p<0.05).Analysis conclusion:(1)After 6 months of lower extremity resistance training,it can effectively reduce the inflammatory factors CRP and IL-6 in the plasma of the elderly with MCI,and increase the muscle factor Irisin,indicating that lower limb resistance training has a significant regulatory effect on the improvement of blood factors in the elderly with MCI.(2)Lower limb resistance training can effectively improve SMI and avoid the occurrence of sarcopenia.(3)Lower limb resistance training can effectively inhibit extracellular protein deposition by up-regulating Irisin and down-regulating CRP and IL-6,thereby improving the structure and function of the central nervous system and improving the cognitive level of the elderly. |
