| Objective: To observe the clinical efficacy of Huangdi Nei Zhen on patients with moderate pain of primary hepatic carcinoma(PHC).To evaluate the safety and clinical advantages of this treatment,and to explore its possible analgesic mechanism.Methods: Sixty patients with moderate pain in PHC who met the inclusion criteria were collected and divided into 30 cases each in the control group and treatment group by random number table method.In addition to conventional symptomatic support,liver protection and antiviral treatment,the control group was given a basic treatment regimen of oral Oxycodone Hydrochloride Prolonged-release Tablets,while the treatment group was treated with Huangdi Nei Zhen regimen on top of the control group.The treatment course of both groups was 4 weeks.Changes in the NRS,KPS,BPI scores and the pain factors Beta-endogenous Opioid Peptide(β-EP)and Endothelin-1(ET-1)were observed before and after treatment in both groups and evaluated for efficacy.The number of painful episodes and the occurrence of adverse effects during the treatment period were also recorded in both groups after treatment.The relevant data of the experiment were statistically analyzed and processed using SPSS 26.0.Results: 1.Baseline comparison: There was no significant difference in the baseline comparison of the two groups before treatment in terms of gender,age,duration of disease,NRS score,KPS score,BPI score,and β-EP,ET-1levels(P > 0.05),which were balanced and comparable.2.Comparison of NRS pain scores: Pain scores of patients in both groups decreased after treatment compared with those before treatment,and the difference was statistically significant(P < 0.05),with decrease in pain being more significant in the treatment group(P < 0.05).3.Comparison of KPS scores: KPS scores of patients in both groups improved after treatment compared with those before treatment,and the difference was statistically significant(P < 0.05),with improvement being more significant in the treatment group(P < 0.05).The patients in the treatment group showed more significant improvement in their functional life status.4.Comparison of BPI scores: All 7 items of BPI scale scores of patients in both groups improved after treatment compared with those before treatment,and the difference was statistically significant(P < 0.05).In the four aspects of mood,sleep,walking ability and interest in life,the treatment group was better than the control group(P < 0.05).5.Comparison of β-EP and ET-1: The β-EP levels in both groups increased and the ET-1 levels decreased after treatment compared with those before treatment,and the differences were statistically significant(P < 0.05),with the β-EP levels in the treatment group being higher than those in the control group(P < 0.05)and the ET-1 levels in the treatment group lower than those in the control group(P < 0.05).The treatment group had better regulation of β-EP and ET-1 levels than the control group.6.Comparison of clinical efficacy: The total effective rate of the treatment group was 86.2%,while the control group was 58.6%.The pain efficacy of the treatment group was better than that of the control group,and the difference was statistically significant(P<0.05).7.Comparison of the number of eruptive pain episodes: The difference in the number of eruptive pain episodes during treatment between the two groups was statistically significant(p < 0.05),with the number of eruptive pain episodes in the treatment group being less than that in the control group.8.Incidence of adverse reactions: The incidence of adverse reactions was41.2% in the treatment group and 75.8% in the control group.The incidence of adverse reactions in the treatment group was lower than that in the control group.Conclusion: Huangdi Nei Zhen combined with western medicine for pain relief can effectively relieve the pain of PHC patients.Compared with the treatment with western drugs alone,the additional use of Huang Di Nei Zhen for pain relief could better improve the KPS and BPI scores,reduce the adverse effects of analgesic drugs and improve the quality of life of patients.The mechanism may be related to the increase of β-EP and the decrease of ET-1. |
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