| OBJECTIVE:To observe the effects of Bufei Dingchuan Decoction on TCM syndrome scores,pulmonary wheeze volume conversion scores,ACT scores and serum YKL-40 levels in patients with chronic persistent bronchial asthma(Lung Qi deficiency syndrome),and evaluate its clinical efficacy and safety.Methods:Collected from June 10,2020 to December 31,2020,65 patients who met the inclusion criteria in the outpatient department of the respiratory department of our hospital were randomly divided into treatment group and control group.One case in the treatment group was lost to follow-up,and one case in the control group withdrew from the trial due to acute exacerbation.Finally,63 cases were observed,31 cases were in the treatment group,and 32 cases were in the control group.The control group was given to Symbicort(160μg/4.5μg/puff×60puff/bottle).1 inhalation each time,2inhalations a day.On the basis of administration of the control group,the treatment group was given Bufei Dingchuan Decoction,one dose per day,300 ml decoction in water,and 150 ml each in the morning and evening.Drug treatment for four weeks.Observe the changes of TCM syndrome scores,pulmonary wheezing volume conversion scores,ACT scores,serum YKL-40 levels and safety indicators before and after treatment in the two groups of patients.Result:1.The total effective rate of the treatment group is 90.32%,and the total effective rate of the control group is 81.25%.The Efficacy of the treatment group is better than that of the control group(P<0.05).2.After treatment,the total score of TCM syndromes of the two groups decreased(P<0.05),and the treatment group was better than the control group(P<0.05).3.After treatment,the volume of wheezing of the two groups of patients decreased compared with that before treatment(P<0.05).4.After treatment,the ACT scores of the two groups were improved to a certain extent(P<0.05),and the treatment group was better than the control group(P<0.05).5.Serum YKL-40 levels of the two groups of patients decreased after treatment(P<0.05).6.There were no obvious abnormal changes in blood routine,urine routine,liver function,kidney function,electrocardiogram and other safety indexes before and after treatment in the two groups.Conclusion:1.Bufei Dingchuan Decoction can reduce the TCM syndrome scores of patients with chronic persistent bronchial asthma(Lung Qi deficiency syndrome);2.Bufei Dingchuan Decoction can ameliorate lung wheezing in patients with chronic persistent bronchial asthma(Lung Qi deficiency syndrome);3.Bufei Dingchuan Decoction can improve the ACT score of patients with chronic persistent bronchial asthma(Lung Qi deficiency syndrome);4.Bufei Dingchuan Decoction can reduce the level of serum YKL-40 in patients with chronic persistent bronchial asthma(Lung Qi deficiency syndrome);5.Bufei Dingchuan Decoction is clinically safe and effective in treating chronic persistent bronchial asthma(Lung Qi deficiency syndrome). |
