| Objective: This topic is to use acupoint application combined with acupoint injection and oral Chinese medicine triple therapy in the treatment of chronic persistent asthma.By comparing the changes of TCM syndrome score,inflammatory factor level,asthma control test(ACT)score,lung function level,T lymphocyte immune function and clinical curative effect of the two groups before and after intervention,we further explore its mechanism of action,and provide reference for asthma control It provides new ideas and methods for the prevention and treatment of asthma.Methods: 60 asthmatic patients with chronic duration(syndrome of lung kidney yang deficiency)who were treated in Affiliated Hospital of Jiangxi University of traditional Chinese medicine from December2018 to August 2020 were collected.According to the principle of random distribution,the patients were divided into observation group(n=30)and control group(n=30).The control group was used salmeterol fluticasone powder inhaler(sullidae)once a day,and gargle after use.On this basis,the observation group was given triple therapy in "dog days" and "Sanjiu period",and one course was completed after one year.The changes of TCM syndrome score,inflammation index,act score,lung function level,T-lymphocyte subsets and clinical efficacy were compared before and after intervention,and the safety of the two groups in the treatment process was observed.Results: 1.In the basic situation: during the experiment,there were 3 cases of shedding,1 case of shedding in the observation group because of unable to adhere to the triple therapy,and 2 cases of shedding in the control group because of stopping Seretide.Finally,a total of 57 patients(29 cases in the observation group and 28 cases in the control group)were included for study and comparison.After examination,it was found that the observation group and the control group were not statistically different in gender,age,course of disease,TCM syndrome score,ACT score,inflammatory index,lung function level and T lymphocyte immune function before the intervention,(P>0.05).2.TCM main symptom score: after treatment,both the two groups could obviously improve the symptoms of wheezing,cough and expectoration,chest diaphragm fullness and wheezing(all P<0.05),but the effect of the observation group was more significant than the control group in improving the main symptoms of traditional Chinese medicine(P<0.05);TCM secondary symptom score: the symptoms of mental fatigue and fatigue in the control group improved evidently(P<0.05),but the symptoms of waist and knee soreness,chills and cold limbs,easy to catch cold did not improve(P>0.05)After the intervention,the symptoms of lumbar and knee soreness,mental fatigue,chilly limbs and easy to catch cold in the observation group were significantly improved(all P<0.01).The observation group has more advantages than the control group in the improvement of TCM secondary symptom score(P<0.05);the control group and the observation group improved significantly in the total score of main symptoms and symptoms of traditional Chinese medicine(P<0.05);In terms of total score of main symptoms and total score of TCM symptoms,both groups were significantly improved after intervention(P < 0.05),there was no improvement in the control group(P>0.05),but the observation group improved significantly(P<0.01).The observation group had more significant improvement than the control group in the total score of main symptoms,the total score of secondary symptoms and the total score of TCM symptoms after intervention(P<0.05).3.Asthma control level: both the observation group and control group could significantly improve the ACT score(P<0.05).however,the observation group has more advantages in improving ACT score than the control group(P<0.05).4.The levels of serum inflammatory factors:Compared with before intervention,eosinophil percentage(EOS%)and C-reactive protein(CRP)in the observation group and the control group did not decrease significantly(P>0.05);and after intervention,there was also no significant difference in inflammatory indexes between the two groups(P>0.05).5.Pulmonary function: After treatment,FEV1% and PEF of pulmonary function indexes in the two groups were increased(P<0.05).However,compared with the control group,the improvement of FEV1% and PEF in the observation group after intervention was not obvious(P>0.05).6.T lymphocyte immune function: the CD4 and CD3 of the control group were not significantly improved,and the CD8 did not decrease(P>0.05).The CD4 and CD3 of the observation group were significantly improved(P<0.01),and the CD8 index was decreased(P<0.05).Compared with the control group,the CD4 and CD3 of the observation group were significantly improved,and the CD8 decreased more significantly(P<0.05).7.Clinical efficacy: in the observation group,there were 29 cases,including 1 invalid case,15 effective cases,11 markedly effective cases,2 clinically controlled cases,the clinical effective rate was 96.55%.In the control group,there were 28 cases,including 8 invalid cases,14 effective cases,6 markedly effective cases,0 clinically controlled case,the clinical effective rate was 71.43%.The observation group was more effective than the control group(P<0.05).8.In the whole process of the study,mild skin redness and pruritus occurred in the observation group after acupoint application,which belonged to normal reaction.Among them,3 patients had small blisters on the skin.They were asked to avoid scratching,disinfected with Iodophor,absorbed by themselves in the later stage,healed well,and no serious adverse reactions occurred.There were no adverse reactions in the control group.Conclusion:Triple therapy combined with Seretide is more effective than Seretide alone in the treatment of chronic persistent asthma(the syndrome belongs to lung and kidney yang deficiency type).It can effectively relieve clinical symptoms,especially in the improvement of chills,cold limbs,easy to catch a cold,mental fatigue,waist and knee soreness secondary symptoms.And can enhance the body immunity,improve the asthma control rate,clinical curative effect is significant.However,there is no obvious effect in inhibiting inflammatory response and improving lung function,which needs further study. |
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