Clinical Observation On Treatment Of Chronic Persistent Bronchial Asthma (Lung Qi-deficiency) With Yupingfengguizhi Decoction

Objective: To observation the clinical effect of bronchial asthma patients staying with chronic persistent period who were treated with Yupingfengguizhi Decoction on the basis of Western medicine.And discussion the efficacy and safety of the decoction in the treatment of bronchial asthma patients staying with chronic persistent period.To explore the basis and reference for the treatment of bronchial asthma in traditional Chinese medicine.All of these are provide evidence-based basis to the combined treatment of traditional Chinese and Western Medicine in treatment of bronchial asthma(deficiency syndrome of Lung-Qi).Methods:72 patients were randomly selected from the lung disease department of Yunnan Provincial Hospital of traditional Chinese Medicine who were diagnosed as chronic persistent period of bronchial asthma and TCM Xiao syndrome of traditional Chinese Medicine(deficiency syndrome of Lung qi).These subjects were randomly divided into the treatment group and the control group,with 36 cases in each group.The patients in the control group were treated with budesonide / formoterol fumarate powder for inhalation therapy,the patients in the treatment group combined with Yupingfengguiuizhi decoction at the therapy of control group.The time of treatment was 3 months.After finishing the treatment,the clinical symptoms,lung function,clinical efficacy and drug safety of the two groups were compared.Results: In the control group,1 case was eliminated because of drug allergy.In the treatment group,1 case fell off and not finished treatment.Both the two group were treated with 35 cases.Through the treatment of three months,the results are as follows:1.Comparison of TCM syndromes: after treatment,the scores of two groups were significantly lower than before treatment,and the differences were statistically significant.The score of treatment group(3.87 + 2.25)was lower than the control group(9.16 + + 2.74),Compared with the control group,the treatment group was superior in the TCM syndromes,and the difference was statistically significant.Comparison of main symptom score(wheezing,shortness of chest,cough and sputum): the scores of patients in both groups were significantly lower than those before treatment,and the differences were statistically significant.The score of the treatment group was lower than that of the control group,and the difference was statistically significant.Comparison of minor symptom score(fatigue drowsiness,spontaneous sweating,chills and easy to exopathy): the scores of the treatment group were lower than those before treatment,and the differences were statistically significant.There was no statistically significant difference between the scores in the control group.At the same time,the integral of the treatment group was lower than the control group,and the difference was statistically significant.2.Comparison of FEV1,FEV1/FVC% and FEV1% : After treatment,the FEV1,FEV1/FVC% and FEV1% of the two groups were all higher than those before the treatment,and the difference was statistically significant.At the same time,the results showed that the FEV1,FEV1/FVC% and FEV1% of the treatment group were higher than those of the control group after treatment,and the difference was statistically significant.3.Comparison of ACT score: After treatment,the ACT scores of the two groups were all increased,and the difference was statistically significant.At the same time,there was no significant difference in ACT scores between the two groups after treatment During the treatment.4.Comparative analysis of clinical efficacy: the effective rate of treatment group was 82.86%,higher than 74.29% in the control group,and the difference was statistically significant.At the same time,the difference of efficacy between the two groups was statistically significant,and the curative effect of the treatment group was better than that of the control group.5.Evaluation of safety indicators: The two groups of safety indicators: blood pressure,heart rate,respiration showed no obvious abnormalities.There was no significant change in blood routine,liver function and renal function before and after treatment.There was no statistically significant difference in the indicators.Conclusion: On the basis of maintaining standardized treatment,Yupingfeng Guizhi decoction,which has the effects of invigorating qi,consolidating exterior and dispersing lung qi and relieving asthma,is superior to the control group in improving the symptoms such as wheezing,cough,expectoration and the like and reducing the recurrence and aggravation of asthma,thereby achieving the purposes of improving the lung function of the patients and improving the quality of life of the patients.It is worthy of clinical popularization and application.