Study On The Correlation Between TCM Syndromes Of Ulcerative Colitis And Blood Coagulation Indexes

Objective:To analyze the correlation between TCM syndromes of ulcerative colitis and blood coagulation indexes,and to explore the tendency of different syndromes combined with blood stasis on the microscopic syndrome differentiation level.Methods:This study included a total of 161 inpatients diagnosed with ulcerative colitis from January 2014 to January 2019 in the Department of Gastroenterology,Beijing Traditional Chinese Medicine Hospital,Capital Medical University.From the HIS-21 system,the patient’s medical records were queried,based on the patient’s clinical manifestations,physical and chemical Examination,combined with "Consensus Opinions on the Diagnosis and Treatment of Inflammatory Bowel Diseases"(2018·Beijing),to establish a patient’s Western medicine diagnosis(clinical type,lesion range,disease stage,severity)According to the information of the four diagnosis clinics of the patients,and in accordance with the"Consensus of Experts in the Diagnosis and Treatment of Ulcerative Colitis in Traditional Chinese Medicine"(2017),the patients’ TCM syndromes are established.Record the patient’s blood coagulation index level.SPSS 24.0 was used to compare the correlation between different TCM syndromes and hemagglutination indexes,and the correlation between the four levels of Western medicine diagnosis(ie clinical type,lesion range,disease stage,severity)and hemagglutination indexes under the same TCM syndrome.Results:1.General information:A total of 161 patients were included in this study,including 81 males and 80 females,with a male to female ratio of approximately 1:1.The age ranged from 17 to 78 years,with an average age of(44.16±15.67)years.The youth group had the largest number(53.4%),the middle-age group followed(24.8%),and the elderly group had the smallest number(21.7%).The course of disease is 1-330 months,with an average of(69.06±67.93)months.Those with a course of≤5 years,5-10 years,and≥10 years account for 57.1%,18.1%,and 24.8%,respectively.In terms of etiology,the traceable causes(60.9%)were cold foods and colds(27.3%),fatigue(12.4%),mood swings(11.8%),hot foods(9.3%),and 39.1%There are no incentives in the patient ’s medical records.2.Distribution of Western medicine diagnosis:distribution of clinical types:8 cases(5%)with initial onset,153 cases(95%)with chronic recurrence;distribution of lesions:26 cases with rectal type(16.1%),83 cases with left colon type(51.67)%),52 cases of extensive colon type(32.3%);disease stage distribution:150 cases in active period(93.2%),11 cases in remission period(6.8%);severity distribution:mild in 59 cases(39.3%),moderate 45 cases(30.0%)and severe 46 cases(30.7%).3.Distribution of TCM syndromes:54 cases of large intestine damp heat syndrome(33.4%)>39 cases of cold and heat miscellaneous syndrome(24.2%)>23 cases of spleen deficiency dampness syndrome(14.3%)>17 cases of spleen and kidney yang deficiency syndrome(10.6%)15 cases(9.3%)of liver depression and spleen deficiency syndrome>11 cases(6.8%)of heat,toxic and heat syndrome>2 cases of deficiency syndrome of yin and blood(1.2%)4.Correlation between different TCM syndromes and blood coagulation indicators:4.1 Compared with other syndromes,the syndromes of heat,toxic,flammability,spleen,kidney and yang are related to prothrombin time(PT),prothrombin activity(PTA),international normalized ratio(INR),thrombin time(TT),and fibrin.There are obvious differences in the levels of six hemagglutination indexes such as fibrinogen(FIB)and fibrinogen degradation product(FDP):4.1.1 The FIB level of the syndrome of heat,poison and heat is higher than all other syndromes(P<0.05);the FIB level of the spleen and kidney yang deficiency syndrome is higher than that of the spleen deficiency dampness syndrome(P<0.05).4.1.2 The FDP level of the heat-toxic flammability certificate is higher than all other syndromes(P<0.05).4.1.3 The TT level of the syndrome of heat poison and flammability and the syndrome of spleen and kidney yang deficiency are lower than that of the syndrome of spleen deficiency and dampness,and the syndrome of cold and heat(P<0.05).4.1.4 The INR level of the heat poison Chisheng syndrome is higher than the cold and heat miscellaneous syndrome,spleen deficiency dampness syndrome,and large intestine damp heat syndrome(P<0.05);the spleen and kidney yang deficiency syndrome is higher than the cold and heat miscellaneous syndrome,large intestine damp heat syndrome(P<0.05)4.1.5 The PT level of the heat poison Chisheng syndrome is higher than the cold and heat miscellaneous syndrome,spleen deficiency dampness syndrome,and large intestine damp heat syndrome(P<0.05);the spleen and kidney yang deficiency syndrome is higher than the cold and heat miscellaneous syndrome,large intestine damp heat syndrome(P<0.05);The PT level of liver depression and spleen deficiency syndrome is higher than that of large intestine damp heat syndrome(P<0.05).4.1.6 The PTA level of the syndrome of heat,poison and heat is lower than the syndrome of cold and heat syndrome,syndrome of spleen deficiency and dampness,and the syndrome of dampness and heat of large intestine(P<0.05);PTA level of liver depression and spleen deficiency syndrome is lower than that of large intestine damp heat syndrome(P<0.05)4.2 The correlation between other syndromes and hemagglutination indexes is not obvious(P>0.05).5.Under the same TCM syndrome,the correlation between the four levels of Western medicine diagnosis(ie,different clinical types,disease scope,disease stage,and severity)and blood coagulation indicators is not obvious.That is,except for the differences in the levels of PT,PTA,INR under different severity of liver stagnation and spleen deficiency syndrome,and the difference in FIB levels between different disease areas under the large intestine damp-heat syndrome,the four levels of diagnosis of the same TCM syndrome and Western medicine There is a clear correlation between blood coagulation indicators.Conclusion:1.The syndrome of heat,toxic and flammability and spleen and kidney yang deficiency syndrome are more likely to be associated with blood stasis than other syndromes,and the two syndromes should be more prominent in the treatment of blood stasis.2.Under the same TCM syndrome,the four levels of UC Western medicine diagnosis(ie,clinical type,lesion range,disease stage,and severity)cannot yet be used as a reference basis for the tendency to stasis.