Professor Zhang Shengsheng's Experience In Data Mining And Clinical Efficacy Evaluation Of Ulcerative Colitis

Background:Ulcerative colitis(UC)is a kind of unclear cause of chronic non-specific inflammatory bowel disease,which is easy to relapse,refractory,and having a certain canceration tendency.In recent years,the incidence of UC has increased obviously,and it has become a difficult and complicated disease.The Clinical treatment is to control inflammation and improve symptoms,but its efficacy is not very satisfied.Traditional Chinese medicine(TCM)has been recognized by the society because of its definite curative effect,less adverse reaction and low recurrence rate.TCM has some advantages and characteristics in the treatment of UC,showing a good clinical prospect.1.Academic Exprience Summury of Professor Zhang Shengsheng in Treating UC base on Data MiningObjective:Using data mining technology to summerize professor Zhang's academic experience in treating UC,in order to providing objective basis for clinical medication.Methods:All the clinical data of outpatients were collected and sorted in clinic,and screened according to the inclusion criteria and exclusion criteria.The research results of 70 cases are analysized and summarized by using the integrated clinical case analysis system.Result:1.General information:In 70 cases,37 cases were male and 33 cases were female.The age ranged from 23 to 79,and the average age was 39.3 years.2.Symptom analysis:The top 10 symptoms were purulent and bloody stools,abdominal pain,diarrhea,fatigue,loose stools,poor sleep,dry mouth,cold limbs,impatient and Tenesmus.3.TCM syndrome analysis:By analysising of TCM syndromes in 70 patients with UC during the first visit,we found that large intestine damp-heat syndrome is the most common,followed by liver-stagnation and spleen-deficiency syndrome,spleen wet Yun syndrome,cold-heat complicated syndrome,spleen and kidney yang deficiency syndrome,and yin and lood deficiency syndrome.4.Medicine frequency analysis:The most commonly used herbs by professor Zhang in the treatment of ulcerative colitis were Chaobaizhu,Sanqi,Diyutan,Baibiandou,Zhihua-ngqi,Muxiang,Ercha,Baishao,Huanglian,Shanyao,Yanhusuo,Xueyutan,Paojiang,Jiaoshenqu,Xianhecao,Yiyiren,Roudoukou,Danggui,Shenghuangqi,Mohanlian,etc.The effect of most herbs is sbout benefiting qi and nourishing blood.Also hemostatic herbs are commonl y used,followed by antipyretics,qi regulating drugs,digestant drugs,etc.The channel-tropis m of medicine was mostly liver,spleen,and stomach,follow by lung,kidney,large intesti ne.5.Relevance analysis:Commonly Used Pair-drugs with strong correlation were Diyu tan-Chaobaizhu,Bibiandou-Chaobaizhu,Ercha-Sanqi,Shanyao-Chaobaizhu,etc.The basic pres cription drugs was composed of Zhihuangqi,Chaobaizhu,Sanqi,Muxiang,Ercha,Diyutan,Ba-ishao,Huanglian,Baibiandou and Shanyao,etc.When impatient and abdominal pain occur ed,Yanhusuo was usually used.When dry mouth and thin pulse occured,Baishao and Sa nqi were used.We found that using Paojiang and Xueyutan and Huanglian together cou Id relieve the symptom of diarrhea,also using Xianhecao,Xueyutan,Yanhusuo and Sanq i could relieve the symptom of abdominal pain.When symptoms of purulent and blood y stools were aggravated,Xuyutan would be used.And when symtoms of fatigue and p oor sleep were alleviated,would be added with Huanglian.6.The main clinical symptom analysis:Through the statistics of score changes of main clinical symptom,we found that treatments for common symptoms like diarrhea,bloody stool and abdominal pain,had good clinical efficacy.Conclusion:1.UC with purulent and bloody stools,abdominal pain,diarrhea,fatigue and watery stools as the main symtoms.According to its clinical manifestations can be attributed to"recurrent dysentery".Large intestine damp-heat syndrome is the most common TCM Syndrome,followed by liver-stagnation and spleen-deficiency syndrome,spleen wet Yun syndrome.2.Through the analysis of commonly used herbs,we found that treatment mostly from"Xu","Yu","Shi","Re" and "Du".The effect of most herbs is about benefiting qi and nourishing blood,combining promoting blood circulation,heat-clearing and Eliminating dampness.The channel-tropism of medicine was mostly liver,spleen,and stomach,follow by lung and kidney.The basic prescription drugs were composed of Zhihuangqi,Chaobaizhu,Sanqi,Muxiang,Ercha,Diyutan,Baishao,Huanglian,Baibiandou and Shanyao,etc.And the clinical effect is significant.2.Clinical Research on the Efficacy of Qingre Huashi Liangxue Huayu Methods in Treating Active Ulcerative ColitisObjective:To investigate the clinical efficacy and safety of Qingre Huashi Liangxue Huayu methods in treating active UC.Methods:The 30 patients were divided into treatment group and control group randomly who were diagnosed as active UC with Large intestine damp-heat syndrome.The treatment group were treated by the prescription of Qingre Huashi Liangxue Huayu Methods combined with mesalazine,while the control group was treated with mesalazine only.After three months of treatment,the therapeutic effect was evaluated by two groups of clinical curative effect,TCM syndrome curative effect,safety index and so on.Result:1.In this study,the ratio of participants in male and female patients was I:1.07.Age group of 30-39 was most common and the average age was 39.3 years.2.After treatment,Comparing the clinical efficacy between the two groups,the treatment group was better than the control group(P<0.05).3.We compared two groups of patients with clinical remission rate and overall effective rate,no obvious difference was founded(P>0.05).The clinical remission rate of treatment group or control group was 53.3%and 21.4%,while the overall effective rate of treatment group or control group was 93.3%and 71.4%.4.Comparing changes of TCM symptoms and signs between the two groups,the treatment group was better than the control group(P<0.05).?5.The treatment group was better than the control group in comparing the apparent effective ratio between the two groups(P<0.05).But we didn't find any obvious difference between the two groups about remission rate and effective rate(P>0.05).6.The treatment group was better than the control group in comparing the improvement of diarrhea of main symptoms between the two groups(P<0.05).But we didn't find any obvious difference between the two groups about the improvement of pus and blood stools and abdominal pain(P>0.05).Conclusion:The treatement of Qingre Huashi Liangxue Huayu methods for active ulcerative colitis is effective and safe,and for the symptoms improved significantly better than mesalazine.