| ObjectiveFirstly,through consulting ancient books and modern medical literature,the research progress and diagnosis and treatment of children’s anorexia in traditional Chinese and Western medicine are deeply understood,especially the discussion on the syndrome of"spleen deficiency and liver prosperity";secondly,on the basis of a certain understanding of the literature,the clinical treatment of children’s anorexia of spleen deficiency and liver prosperity is based on the experience of tutors(Tiaogan Lipi Granule).At the same time,when consulting the literature,we know that serum neuropeptide Y can regulate food intake,so we detected the serum neuropeptide Y levels of two groups of children before and after treatment,and preliminarily explored the mechanism of the tutor’s experience prescription in treating anorexia of children with spleen deficiency and liver hyperactivity.MethodA total of 70 children with anorexia who met the criteria were randomly divided into two groups with 35 cases in each group.In the course of the research,2 cases of the two groups fell off,and 66 cases of clinical data were finally collected.In the treatment of drug use,the treatment group was given Tiaogan Lipi Granule orally,while the control group was given Bifidobacterium tetralogy live bacteria tablets orally for 4 weeks.In terms of observation indicators,it mainly includes the evaluation of TCM syndrome integral scale and the determination of serum neuropeptide Y level.Specific indicators were evaluated as follows:TCM syndrome integral scale evaluation time was before treatment,2 weeks after treatment,4 weeks after treatment;serum neuropeptide Y level determination time was before treatment and 4 weeks after treatment,respectively.Due to the limitations of various conditions,24 serum indices were collected from 66 children,including 13 in the treatment group and 11 in the control group.In the aspect of result discussion,this study mainly observes the clinical effect of Tiaogan Lipi Granule in treating infantile anorexia of spleen deficiency and liver prosperity by comparing the improvement of TCM symptom integral before and after treatment,and preliminarily explores the mechanism of Tiaogan Lipi Granule in treating infantile anorexia of spleen deficiency and liver prosperity by observing the changes of serum neuropeptide Y level before and after treatment.Result1.Analysis of curative effect of diseaseThe marked cure rate was 51.52%,87.88%and the total effective rate was 84.85%and 100%in the treatment group after 2 and 4 weeks of treatment,respectively;the marked cure rate was 21.21%,42.42%and the total effective rate was 48.48%and 87.88%in the control group after 2 and 4 weeks of treatment,respectively;the disease effective rate of the two groups was 48,48%and 87.88%.Surface,there are differences between the two groups,and the curative effect of the treatment group is better than that of the control group.2.Analysis of curative effect of TCM syndromesThe marked cure rate of the treatment group was 33.3%,84.9%and the total effective rate was 90.9%and 100%respectively after 2 and 4 weeks of treatment 3 while the marked cure rate of the control group was 6.1%,21.2%and the total effective rate was 36.4%and 81.8%respectively after 2 and 4 weeks of treatment.The comparison of the curative effect of TCM syndromes between the two groups showed that the p value was less than 0.05,indicating the treatment of TCM syndromes.In terms of efficacy,there are differences between the two groups before and after treatment,and the curative effect of TCM syndromes in the treatment group is better than that in the control group.3.Improvement of symptom scoresThe scores of main symptoms and secondary symptoms of the two groups after 2 weeks of treatment and 4 weeks of treatment were compared and analyzed.The results showed that the therapeutic effect of the treatment group was better than that of the control group in improving the appetite,appetite,anxiety and sleep of the children.In terms of improving children’s facial color,the results of infra-group analysis showed that the symptoms scores of the two groups were significantly improved,and the treatment group was better than the control group after 4 weeks of treatment.In the aspect of improving hiccup in children,the intra-group comparative analysis showed that the syndrome score of the treatment group improved significantly after 2 and 4 weeks of treatment,while that of the control group improved only after 4 weeks of treatment;there was no significant difference between the two groups.In terms of improving abdominal distension and excessive drinking,both groups improved significantly after 4 weeks of treatment,and the improvement of abdominal distension and excessive drinking in the treatment group was more obvious than that in the control group.In terms of improving the symptoms of mental fatigue,the treatment group improved after 2 and 4 weeks of treatment,but there was no significant difference between the control group and the pre-treatment group.The comparison between the two groups indicated that the improvement of mental fatigue in the treatment group was more obvious than that in the control group after 4 weeks of treatment.In improving the stool of children,there were differences between the treatment group and the control group,and there was no significant difference between the two groups.4.Serum neuropeptide Y levelSerum NPY levels of 24 children were collected from 66 patients.Serum NPY levels of the two groups were measured before and after treatment for 4 weeks respectively.The results showed that serum NPY levels of the two groups were higher after treatment for 4 weeks than those before treatment,and there was statistical significance.Serum NPY levels of the treatment group were higher than those of the control group in comparison between the two groups.Serum NPY levels of the treatment group were higher than those of the control group in comparison between the two groups.Highly significant,indicating that the treatment group is better than the control group in improving the serum neuropeptide Y level.ConclusionOral Tiaogan Lipi Granule has good curative effect on infantile anorexia of spleen deficiency and liver exuberance type.Its curative effect is not only reflected in the curative effect of disease,but also can improve the appetite,appetite,irritability and stool of children.In this study,the level of serum neuropeptide Y was measured before and after treatment in two groups of children.It was speculated that the mechanism of Tiaogan Lipi Granule in treating anorexia of children with spleen deficiency and liver exuberance might be related to the increase of serum neuropeptide Y level in children. |
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