Observation On Clinical Efficacy And Safety Of Zhitong No.1 In Treating Chronic Wounds And Producing Muscle Analgesia

Objective:(1)To observe the clinical effect of Zhitong No.1 combined with Shengji Xiangpi Ointment for the external treatment of dampness-heat poisoning syndrome on chronic wounds.(2)Observe the safety of Zhitong No.1 topical medicine.Methods: 72 cases of chronic wounds that met the inclusion criteria were randomly divided into a control group and a treatment group,36 cases in each group,and corresponding basic treatments such as hypoglycemic and antihypertensive treatment were given according to the patient's condition,and debridement treatment was appropriately given according to the wound situation.Then,the wounds were treated with topical drugs,and the control group was replaced with conventional external muscle-like elephant skin ointment.The treatment group was replaced with analgesic No.1 dressing on the basis of the control group.The dressing was changed once a day,and the observation time was 2 weeks..The local wound syndrome score scale was used to observe the wound granulation granules,wound granulation color,wound wound swelling,wound granulation volume,wound exudation,etc.before and after the treatment of chronic wounds(after debridement),week 1,and week 2.The patient's pain scores before and after treatment,the first week,and the second week of dressing change.In addition,the wound size and anxiety self-rating scale scores before and after treatment were observed.In terms of safety indicators,liver and kidney functions were mainly observed before and after treatment.Results:(1)Regarding the integral curative effect of local wound syndrome,after 2 weeks of treatment,compared with before treatment,the total effective rate of the treatment group was 96.56%,and the total effective rate of the control group was 74.19%.The treatment group was better than the control group(p <0.05);(2)In terms of the wound area efficacy,the total effective rates of the treatment group and the control group were 82.76% and 70.97%,so there was no significant difference in the efficacy of the two groups(p> 0.05);(3)Comparison between groups: In terms of improving the granulation color of the wound surface,there was no statistically significant difference between the two groups(p> 0.05)before treatment,after 1 week,and after 2 weeks.There was no significant difference in theeffects between the two groups;there was no statistical difference between the two groups(p> 0.05)in terms of the improvement of wound granulation granules and wound granulation volume before and after 1 week(p> 0.05).There was no significant difference;after 2 weeks,the granulation granules and the amount of granulation on the wound surface were statistically significant compared between the two groups,and the treatment group was better than the control group(p <0.05);After 2 weeks compared with before treatment,the difference between the two groups was not statistically significant(p> 0.05);(4)In terms of reducing pain score,after 2 weeks compared with before treatment,the treatment group was superior to the control group(p < 0.05);(5)Comparison within the group: In terms of the color of the wound granulation,the granulation of the wound granulation,and the amount of granulation of the wound,the difference within each group was statistically significant after 1week compared with that before treatment and after 2 weeks compared with 1 week later Significance(p <0.05),in terms of lowering pain scores,the comparison of each group before and after treatment was statistically significant(p <0.05);in terms of reducing the anxiety self-assessment scale,the difference between the two groups after treatment and before treatment There is a statistical difference(p <0.05);(6)There is no statistical difference between the two groups in the safety test(liver and kidney function)before and after treatment(p> 0.05),indicating that the two groups have liver and kidney function before and after treatment There is no obvious difference,so Zhitong No.1 has no obvious liver and kidney injury.Conclusion:(1)Zhitong No.1 combined with Shengji Xiangpi Ointment in the treatment of damp-heat poisoning chronic wounds can promote the growth of granulation granules and increase the amount of granulation in the wound,which is better than the control group;(2)Zhitong No.1 combined Shengji Xiangpi Ointment Obviously improve the pain of patients,better than the control group;(3)The drug has no obvious liver and kidney function damage,has good safety,and has no obvious adverse reactions.It can be used in clinical practice.