Clinical Observation Of Wujin Bixie Prescription In The Treatment Of Hyperuricemia With Liver And Spleen Damp-heat Syndrome

Objective To investigate the clinical efficacy and safety of Wujin Bixie prescription in the treatment of hyperuricemia with liver and spleen damp-heat syndrome.Methods Seventy-two patients who accorded with the selected standard subscribed the informed consent form and divided into the test group and control group with thirty-six cases in each group randomly according to the research method.The two groups of the patients were treated with basic therapy.The test group of patients were given Wujin Bixie prescription orally while the control group of patients were given allopurinol tablets orally.They were treated for four weeks and set up cases observation tables.To record the all of the pateints' clinical symptoms,syndrome scores,and interrelated lab indicators(serum UA,uric PH,FBG,TC,TG...)in the before and after treatment detailedly.At the end of the observation,to count the syndromes scores,and use the SPSS23.0 statistical software that P<0.05 was statistically significant to analyze all of the data,and evaluate the clinical efficacy and safety in the last.Results 1.The both of groups finished sixty-seven cases in all,and the test group lost two cases and the control group lost three cases in the end of the research.The data of the two groups were comparable in the before treatment.The serum UA of the every group was abated and was statistically significant in the after treatment(P<0.05),and was distinctly different compared with the control group(P<0.05).In the way of reducing serum UA,the total efficacity ratio of the test group was 76.47% while the control group was 51.52%,and drew a conclsion that the test group was better than the control group(P<0.05).2.In the terms of the syndrome scores,the difference of two groups was statistically significant(P<0.05).The test group better than the control group in the total efficacy ratio of the symptoms(P<0.05),in which the total efficacy rate of the test group was 88.24% and the test group was 39.39%.3.Their differences were statistically significant(P<0.05),that the uric PH of the test group was risen compared with the before treatment and the FBG and TG were reduced.There were not statistically significant(P>0.05)in the control group of the TC,HDL and LDL compared with the before the treatment.So the test group were better than that of the control group in the rise of the uric PH or the decrease of the FBG and TG.4.In terms of safety,the adverse reaction rate of the test group and the control group were 5.88% and 12.12% in the after treatment.Both of the two groups of the safety indicators did not show the obvious difference in the before and after treatment,that included liver function,kidney function,vital sign,blood routine,urine routine,feces routine and electrocardiogram.Conclusion Wujin Bixie prescription can decrease the patients' serum UA,FBG and TG and raise uric PH in the treatment of hyperuricemia with liver and spleen damp-heat syndrome,and also improve patients' clinical symptoms and signs,with fewer adverse reaction,indicating that was effective and safety.