A Clinical Study Of Wenjing Tongluo Powder With The Help Of Kneecap With Carrying Drug And Of Microneedle Penetration On The Treatment Of Cold-dampness Type Knee Osteoarthritis

Objective:To confirm that wenjing tongluo powder with the help of kneecap with carrying drug and of microneedle penetration can relieve the pain symptom of patients with cold-dampness type knee osteoarthritis(KOA),improve the function of knee joint,and improve the compliance and quality of life of KOA patients.Methods:From September 2018 to December 2019 in Jiangsu Province Hospital of Chinese Medicine,a total of 45 outpatients with knee osteoarthritis meeting the inclusion criteria are randomly divided into three groups:15 cases in experimental group(wenjing tongluo powder with the help of kneecap with carrying drug and of microneedle penetration),15 cases in the first control group(layers adjusting external application therapy),15 cases in the second control group(voltaren).With 1 case shedding,eventually entering the data analysis are 44 cases.A full treatment cycle of the 3 groups lastes for 4 weeks.The 4 time nodes are compared,including prior treatment,during treatment(the 2nd and 4th week)and 1 month follow-up after treatment.The main efficacy indicators are:WOMAC score;secondary outcome measures:pain threshold;Safety index:local skin irritation reaction.Results:1.WOMAC score,tenderness threshold and coldness threshold:after the fourth week of treatment,the WOMAC score(pain,stiffness,difficulty in daily activities),tenderness threshold and coldness threshold of the three groups of patients are significantly different from those prior treatment,and the indicators are significantly improved,indicating that the treatment methods of the three groups are effective in treating cold-dampness type KOA.2.The 2nd week after treatment,there are not statistically difference between the three groups in WOMAC pain,stiffness,difficulty of daily activity score and tenderness threshold.While in respect of cold pain threshold,the experimental group have significant difference compared with the second control group,indicating that the experimental group in improving the cold pain threshold is superior to the second control group in the early days,and is comparable to the first control group.There are significant differences in WOMAC pain and stiffness scores between the first control group and the second control group,indicating that the first control group is superior to the second control group in relief of joint pain and stiffness in the early days.3.At the 4th week after treatment,the difficulty score of WOMAC daily activities in the experimental group is statistically significant compared with that in the second control group,and there is no significant difference between the experimental group and the first control group,indicating that the experimental group is better than the second control group in improving daily activities of the knee joint after the treatment laste for a period of time,which is equivalent to the first control group.The experimental group and the first control group have significant differences in WOMAC pain and stiffness scores compared with the second control group,indicating that the experimental group and the first control group are better than the second control group in alleviating knee pain and stiffness after treatment for a period of time.In terms of tenderness threshold and cold pain threshold,there is no significant difference among the three groups,indicating that the improvement of cold pain threshold in the experimental group is only significant in the early days,but slightly decreases after a period of treatment.4.In terms of tenderness threshold,there is no significant difference between the three groups at the 2nd and 4th week after treatment,indicating that the experimental group and the first control group are not superior to the second control group in alleviating tenderness in the medial joint space of the knee joint.Conclusion:Wenjing tongluo powder with the help of kneecap with carrying drug and of microneedle penetration can effectively treat cold-dampness type KOA,easy to use,good safety,better clinical effect than voltaren,and comparable to layers adjusting external application therapy,worthy of clinical promotion.