To Observe The Curative Effect Of Guizhishaoyaozhimu Decoction In The Treatment Of Cold Dampness Type Of Knee Osteoarthritis

Objective: A randomized controlled clinical research methods to observe the clinical curative effect of added peony and anemarrhena decoction in the treatment of cold and dampness obstruction syndrome of knee osteoarthritis(KOA),for its extensive use to provide a certain theoretical basis.Methods:60 patients enrolled in the study,and randomly divided into Chinese medicinal observation group 30 cases and celecoxib capsule control group cases,the number of cases was designed according to the treatment group: control group = 1: 1.The observation group taking “added peony and anemarrhena decoction” orally and control group using celecoxib capsule which is recognized as positive treatment drug.Two weeks for a period of treatment,continuous treatment of 2 courses.Observing before treatment and after trertment of1 course,after trertment of 2 courses,after three months,treatment,comparison of two groups of patients the clinical symptom,WOMAC score,score of knee osteoarthritis symptoms and total efficiency.Results:(1)Added peony and anemarrhena decoction and celecoxib capsule group both can improve the symptoms and signs of KOA patients,reduce pain,improve quality of life.(2)Comparison of clinical efficacy at the end of treatment :the treatment group,a total effectiveness rate of 86.67%;the control group,a total effectiveness rate of 83.3%.The efficiency of two groups there was no statistically significant difference before and after treatment(P>0.05),added peony and anemarrhena decoction and celecoxib capsule group in treatment of cold and dampness obstruction syndrome of KOA effect quite.(3)After 1 course of treatment: In clinical symptoms score,the two groups can reduce the integral level of a different degree,and there is significant difference(P<0.05),there was no significant difference between the two groups(P > 0.05),but from the average of 1 treatment after treatment,the control group were better than those in the treatment group.(4)After 2 courses of treatment,compared with before treatment and 1 course of treatment,the two groups can reduce the patients with the evaluation scale and clinical symptom score(P < 0.05),suggesting that added peony and anemarrhena decoction and celecoxib on KOA have the curative effect,and the effect of the treatment group is better(P < 0.05,in addition to the pain).There was no significant difference between the two groups(P > 0.05).The treatment group was better than the control group in improving pain.(5)3 months after the end of treatment results: compared with before treatment,the two groups can effectively reduce the scale and clinical symptom score(P < 0.05);the treatment group than the control group(P < 0.05),suggesting that added peony and anemarrhena decoction and celecoxib have long-term effects on the KOA.Long term effect of added peony and anemarrhena decoction treatment group could better.Conclusion: There is a close and long-term clinical efficacy of certain added peony and anemarrhena decoction in the treatment of cold dampness type of knee osteoarthritis,patients can effectively relieve pain,relieve the clinical symptoms and signs.The effect of celecoxib group was faster than that of the Added peony and anemarrhena decoction in the treatment of pain,and the short-term curative effect was more obvious,the long-term curative effect of added peony and anemarrhena decoction is more obvious.