A Meta-analysis Of Vitamin B6 In Preventing Chemotherapy Drugs-induced Hand-foot Syndrome

Background: Hand-foot syndrome(HFS)is a common dermal toxicity caused by chemotherapy drugs,which is dose-dependent.In severe cases,it can lead to reduction or even withdrawal of chemotherapy drugs.Many literatures report that pyridoxine has the effect of preventing hand-foot syndrome,but the efficacy is uncertain.Aim: To objectively evaluate the efficacy of pyridoxine in preventing hand-foot syndrome caused by chemotherapy drugs.Methods: We searched CNKI,Pubmed and Maites for study reporting the efficacy of and pyridoxine to prevent hand-foot syndrome in patients with cancer on the use of keyword search.We performed a meta-analysis using the incidence rate of hand-foot syndrome as an indicator of pyridoxine efficacy.Publication bias was performed to evaluate the stability of the study results.Result: We retrieved 11 related literatures(a total of 1,367 patients with cancer).The efficacy of pyridoxine in the prevention of hand-foot syndrome was significantly different compared with the control group [P > 0.05,OR=0.81(95% CI: 0.65-1.03)].Sensitivity analysis showed that there were2 studies with publication bias.Conclusion: Pyridoxine cannot effectively prevent hand-foot syndrome during chemotherapy in cancer patients.