Correlation Research Of Depressive Disorder And Cognitive Dysfunction In Epilepsy Patients

Objective: This research is aimed to study the influence factors and correlation of depression disorder and cognitive dysfunction in epilepsy patients.Methods: 240 patients with epilepsy who were admitted to the First Hospital in Jiaxing from November 2015 to October 2017 and eligible for the study were collected.By using the Chinese version of Min-International Neuropsychiatric Interview(MINI)and the Montreal Cognitive Assessment-basic(Mo CA-B)to assess depression status and cognitive function of all the selected patients.Then according to the assessment of depression status,all the objects of study were divided into the depression disorder group and the non-depressive disorder group.According to the assessment of cognitive status,all the objects of study were divided into cognitive dysfunction group and non-cognitive dysfunction group.By using Beck Depression Inventory-II(BDI-II)to assess the severity of depressive disorder of all the patients with depression.Eventually,by using statistical methods to analyze gender,age,course of disease,seizure type,seizure frequency,the number of antiepileptic drugs(AEDs)taken and other factors effect on depression disorder and cognitive function in epilepsy patients.To further analyze the correlation between depressive disorder and cognitive dysfunction in epilepsy patients.Results: 1.The incidence of depression disorder in 240 epilepsy patients was about 28.75%.There was no statistically significance in comparing the differences in gender,age,level of education,marital status,age of onset,attacking lasting time and seizure type between the depression disorder group and the non-depression disorder group(P>0.05).But the differences in the course of disease,seizure frequency and the number of AEDs taken were ststistically signigicant(p<0.05).thereinto,the course of disease,seizure frequency and the number of AEDs taken were the risk factors for epilepsy patients with depression disorder(OR all>1,P<0.05),and the effect of taking AEDs was more significant(P<0.01).2.The incidence of cognitive dysfunction in epileptic patients was about 32.08%.There was no statistically significance in comparing the differences in gender,level of education,age of onset,attacking lasting time,marital status and seizure type between the cognitive dysfunction group and non-cognitive dysfunction group(P>0.05).But the differences in age,the course of disease,seizure frequency and the number of AEDs taken were statistically significant(P<0.05).Thereinto,age,course of disease,and the number of AEDs taken were significant risk factors of epilepsy patients with cognitive dysfunction(OR all >1,P<0.01),but the seizure frequency had a small effect on them(OR=1.146,P>0.05).3.The score of BDI-II and Mo CA-B is significant negative correlation(r=-0.911,P<0.01).Analysis of covariance indicates that depression disorder and cognitive dysfunction had an influence on each othe(F=7.957,P<0.01),especially in fluency(F=7.264,P<0.01)and orientation(F=15.016,P<0.01).Conclusion:1.The course of disease,seizure frequency and the number of AEDs taken are the risk factors for the epilepsy patients with depressive disorder,especially the effect of the number of AEDs taken.2.Age,course of disease,seizure frequency and the number of AEDs taken are risk factors for epilepsy patients with cognition dysfunction.The influence of age,course of disease and the number of AEDs taken are very significant,but the influence of seizure frequency is small.3.Depression disorder and cognitive dysfunction in epilepsy patients were positively correlated,the more severe the depression,the more obvious the cognitive impairment.4.Depression disorder and cognitive dysfunction in epilepsy patients interact with each other,mainly in the two aspects of fluency and orientation.