| Objective:To observe the effects of butyphthalide on cognitive function,serum S100 B protein and EDNF expression level in epileptic patients,and analyze the relationship between cognitive function and serum S100 B protein and EDNF expression level in patients with epilepsy in order to provide the basis for clinical application of butyphthalide.Methods:Collection in November 2018 in November 2019 from jiamusi university first affiliated hospital neurologist outpatient service and emergency treatment,ward focal seizures of epilepsy patients,a total of 56 cases of epilepsy group,All met the selection criteria,The patients were randomly divided into experimental group and control group.Another 30 healthy physical examinees were selected as the health group at the same time.Gender,age and years of education were matched with epilepsy patients,There was no history of epileptic seizures or neurological diseases,and all physical examination indexes were within the normal range.The control group was treated with sodium valproate sustained release tablets.The experimental group was treated with sodium valproate sustained release tablets and butylphthalide capsules.for 6 months,The Cognitive function of patients in the two groups was assessed by the Montreal Cognitive Assessment(MoCA)at the three time points before treatment,3 months after treatment and 6 months after treatment,and the serum concentrations of S100 B and BDNF were measured.Results:1.Comparison of general information and serum S100 B and BDNF levels between the epilepsy group and the healthy group: there were no statistically significant differences in age,sex and years of education between the two groups(P>0.05).The concentration of S100 B protein in the epilepsy group was higher than that in the healthy group,while the concentration of BDNF was lower than that in the healthy group(P<0.05).2.There were no statistically significant differences in gender,age,years of education and course of disease between the experimental group and the control group(P>0.05).3.Comparison of MoCA scores between the experimental group and the control group:there was no statistically significant difference in MoCA scores between the two groups before treatment(P>0.05);during the treatment period,the MoCA scores of the experimental group showed an increasing trend and were higher than those of the control group at the same time node,and the difference was statistically significant(P<0.05).4.Comparison of serum S100 B protein between the experimental group and the control group: there was no statistically significant difference in serum S100 B protein concentration between the two groups before treatment(P>0.05),while serum S100 B protein concentration in the experimental group showed a downward trend during treatment,and was lower than that in the control group at the same time node,and the difference was statistically significant(P<0.05).5.Comparison of serum BDNF between the experimental group and the control group:there was no statistically significant difference in BDNF concentration between the two groups before treatment(P>0.05).During the treatment period,the serum BDNF concentration in the experimental group was on the rise and higher than that in the control group at the same node,with statistically significant difference(P<0.05).6.Correlation analysis of S100 B and BDNF with MoCA: S100 B was not correlated with MoCA before treatment in the experimental group(r=-0.327,P>0.05),and the concentration of S100 B protein was negatively correlated with MoCA score at 3 and 6 months of treatment,with r value being(r=-0.472,r=-0.411,P<0.05).BDNF concentration in the test group was positively correlated with MoCA score at each time node,and the R value was(0.463,0.503,0.542,P<0.05),which was statistically significant.7.Conclusions:1.Butylphthalide may have a protective effect on cognitive function in epileptic patients.2.Butylphthalide can reduce serum S100 B protein concentration in epileptic patients,and the decreased level is positively correlated with the improvement degree of cognitive function.3.Butylphthalide can increase the expression level of serum BDNF in epileptic patients,and the concentration of BDNF is positively correlated with cognitive function. |
