Detection And Significance Of Serum 25-hydroxyvitamin D Levels In Adults Atopic Dermatitis

BackgroundAtopic Dermatitis(AD)is a chronic,inflammatory skin disease characterized by itching,which is associated with heredity,skin barrier dysfunction,and immune disorders.Skin microecological changes,such as increased colonization of S.aureus and reduced microbial diversity,can also induce AD.Vitamin D is a fat-soluble hormone steroid.It is well known that vitamin D deficiency can cause rickets or osteomalacia.Recently,related studies have found that vitamin D deficiency is also associated with allergic diseases,including atopic dermatitis,asthma,chronic urticaria,Allergic contact cdermatitis,etc.But the research on vitamin D and atopic dermatitis is mostly limited to children,there are few studies report that the significance of serum 25-hydroxy vitamin D levels in adult patients with atopic dermatitis.ObjectiveThis study was designed to analyze the difference of serum 25-hydroxyvitamin D levels in adults with atopic dermatitis and healthy people,and to analyze the relationship between serum levels of 25-hydroxyvitamin D and the severity of adult atopie-dermatitis patients and its related laboratory indicators.At the same time,the effect of Body mass index(BMI)on serum 25-hydroxyvitamin D level and the severity of atopic dermatitis was analyzed.MetlhodFrom June 2018 to December 2018,patients with atopic dermatitis were collected from Qilu Hospital Affiliated to Shandong University,as AD group.At the same time,control group were collected from Qilu Hospital Medical testing Center.Serum 25-hydroxyvitamin D levels(Were divided into vitamin D deficiency group and vitamin D insufficient group),serum total IgE levels,and eosinophils counts and percentage of eosinophils were measured in the AD group.Use SCORAD score to represent the severity of disease in AD group.Also measured the Serum 25-hydroxyvitamin D levels in control group.At the same time the height and weight information were collected in AD group,aim at to calculate the Body mass index(Were divided into normal weight group and overweight/obesity group).Using SPSS 19 software to analyze the statistical data.ResultIn this study there are 53 patients in AD group(including 28 patients in vitamin D deficiency group,25 patients in the vitamin D insufficient group;and 33 patients in normal weight group,20 patients in overweight/obesity group),and 57 people in control group.I.Gender:There was no significant difference in gender composition between AD group and the control group,vitamin D deficiency group and the insufficient group,normal weight group and overweight/obesity group(P=1.000,0.162,and 0.075,respectively).2.Age:There was no significant difference in age composition between AD group and control group,vitamin D deficiency group and insufficient group,normal weight group and overweight/obesity group(P= 0.616.、0.630 and 0.097,respectively).3.Serum 25(OH)D level:The average level of Serum 25(OH)D in the AD group was(21.28±7.11)ng/mL and in control group was(24.41±5.08)ng/mL.The level of Serum 25(OH)D in AD group was lower than that in control group,and the difference between the two groups was statistically significance(t’=2.640,P=0.010).4.Serum 25(OH)D level and severity of disease in the AD group:the mean level of SCORAD score in vitamin D deficiency group was(37.632±12.082)points and in vitamin D insufficient group was(30.176±12.814)points.The severity of disease in vitamin D deficiency group was more serious than vitamin D insufficient group.The difference between the two groups was statistically significance(t=2.18,P=0.034);the 25(OH)D level was negatively correlated with SCORAD,and the correlation was statistically significance(r=-0.281,P = 0.042).5.Serum EOS count,EOS%and severity of disease in AD group:The serum EOS count and EOS%was positively related to SCORAD,and the correlation was statistically significance(r= 0.417 and 0.378,respectively;P=0.002 and 0.005,respectively).6.BMI and severity of disease:The mean SCORAD score in normal weight group was(30.6±11.57)points and in overweight/obesity group was(39.91±13.09)points.Compared with the normal weight group,the overweight/obesity group was more sevious,and the difference was statistically significance(t=-2.701,P=0.009).The body mass index BMI was positively correlated with the severity of disease,the correlation was statistically significance(r=0.331,P=0.016).7.BMI and serum total IgE levels:The mean/median serum total IgE level in normal weight group and overweight/obesity group was 150.17/99.8 and 1617.1/289IU/mL.Serum total IgE levels were significantly higher in overweight/obesity group than in normal weight group,and the difference between the two groups was statistically significance(P=0.001).Also found that BMI was positively correlated with serum total IgE,but the correlation was no statistically significance(r=0.425,P=0.002).8.The correlation between serum 25(OH)D level with serum total IgE level,body mass-index,serum EOS count and EOS%was no statistically significance(r=0.102,-0.047,-0.080 and-0.061,respectively;P= 0.469,0.737,0.570 and 0.663,respectively).As well,the difference between severity of disease and serum total IgE levels was no statistically significance(r=0.236,P=0.089).ConclusionCompared with healthy adults,adults with atopic dermatitis have lower serum 25-hydroxyvitamin D levels,and an increase in body mass index and a decrease in vitamin D levels in adults with atopic dermatitis may aggravate the patient’s condition.Weight control and vitamin D supplementation may be beneficial in improving the condition of adults with atopic dermatitis.