| Background:Immune abnormalities exist in children with Atopic Dermatitis(AD).Many immune indexes are associated with the pathogenesis of AD,while the relationship between immunoglobulin deficiency and AD is controversial.Object:To compare the levels of immunoglobulin indexes between children with AD and normal children,and to explore the correlations between humoral immunity condition and the severity of disease as well as clinical manifestations in children with AD.Methods:Totally 435 AD children with age of 0 to 72 months were selected.The levels of serum immunoglobulin indexes in peripheral blood were detected,including immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA),immunoglobulin E(IgE)and eosinophil count(EC)and types of IgE specific allergens.Record the history of familial allergic disease and the presence of dry skin.The Objective Atopic Dermatitis Scoring Index(O-SCORAD)was used to evaluate the severity of disease in children with AD.In the same period,the levels of the immunoglobulin indexes and EC value were detected in 293 normal children.The classified variables between normal children and children with AD were compared by chi square test,and the numerical variables were compared by t test.The correlation test of classified variables in children with AD was processed by Spearman correlation analysis,and the correlation test of numerical variables conformed to normal distribution was processed by Pearson correlation analysis.Partial correlation was performed after the exclusion and correction of gender confounding.The data is divided into monthly age groups and statistics respectively.Results:In the children with age of 0 to 6 months,the ratio of male in children with AD was higher than that in normal children.In the children with age of 13 to 36 months,the IgM level in children with AD was lower than that in normal children.In the children with age of 7 to 12 months,there was a weak negative correlation between O-SCORAD and IgA.Except for the children with age of 7 to 12 months,the IgE level of children with AD was obviously higher than that of normal children in every age bracket.In the children with age of 0 to 72 months,the number of IgE specific allergens was positively correlated with IgE value in children with AD.In the children without mentioned above,there were no significant differences in immunoglobulin indexes between children with AD and normal children,and showed no correlation with OSCORAD,number of Ig E specific allergens,family history and dry skin.In the children with age of 0 to 72 months,the EC value of children with AD was higher than that of normal children,and there was weak positive correlation between EC value and OSCORAD in AD children with age of 0 to 6 months and 13 to 36 months.Except for the children with age of 7 to 12 months,the number of IgE specific allergens was weakly correlated with O-SCORAD in every age bracket.In the AD children with age of 0 to 6 months and 13 to 72 months,dry skin might be associated with O-SCORAD,which expressed as more serious skin lesions in children with dry skin.In the children with age of 13 to 36 months,there was a extremely weak positive correlation between EC value and IgE specific allergens.In the children with age of 7 to 12 months,the family history of allergic diseases might be related to the number of IgE specific allergens in children with AD,which expressed as more IgE specific allergens in children with family history positive.There were correlations between O-SCORAD and allergens such as milk(age of 0 to 6 months),cat fur(age of 7 to 12 months),cashew,house dust allergy(age of 13 to 36 months),milk,egg,cypress,elm and willow(age of 36 to 72 months).Conclusions:There is an evanescent reduction in IgM value in children with AD,and the persistent reductions of IgA,IgG and IgM are not observed.The levels of IgA,IgG,and IgM show no long-term correlations with the severity of the disease.Children with AD are unnecessary to receive a continuous immunopotentiation therapy. |
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