A Comparative Study On The Relationship Between Serum Vitamin D And Blood Eosinophil Granulocyte In Healthy People And Patients With Chronic Obstructive Pulmonary Disease

BackgroundVitamin D affects bone metabolism and calcium homeostasis,and has anti-inflammatory and immunomodulatory effects.Blood eosinophil granulocyte(Eos)is involved in the maintenance of human homeostasis and immune regulation.Eos plays an important role in the diagnosis and prognosis of chronic obstructive pulmonary disease(COPD).However,the relationship between vitamin D deficiency and EOS in healthy individuals and patients with COPD remains unclear.ObjectiveTo investigate the status of vitamin D deficiency in the healthy adults and patients with chronic obstructive pulmonary disease(COPD)and the relationship between the level of serum vitamin D and blood eosinophil.MethodsA total 6163 healthy were divided into severe deficiency group(<10ng/ml),deficiency group(≥10 and<20 ng/ml),insufficient group(≥20 and<30 ng/ml)and normal group(≥30ng/ml).67 COPD patients were enrolled retrospectively,and the 67 healthy people was matched according to age,sex and BMI in the physical examination center of our hospital during the same period.Routine blood data,body mass index(BMI)and other indexes were recorded.Vitamin D levels were compared and logistic regression models were used to investigate the association between 25(OH)D levels and EOS.ResultsThe abnormal rate of 25(OH)D(<30 ng/ml)in healthy people was 85.31%,89.29%in women which was significantly higher than men.25(OH)D levels in June,July,and August were significantly higher than those in December,January,and February.Blood eosinophil levels were the lowest in the 25(OH)D severe deficiency group in healthy people,followed by deficiency group and insufficient group,and the highest in the normal group(P<0.05).Multivariable regression analysis showed that older age,higher BMI,and elevated vitamin D levels were risk factors for elevated blood eosinophils.The serum level of 25(OH)D was lower in COPD group(19.66±7.87ng/ml)than in healthy controls(26.39±9.28ng/ml),and the abnormal rate of serum 25(OH)D in COPD group(91%)was significantly higher than that in healthy controls(71%)(P<0.05).Reduced 25(OH)D level is a risk factor for COPD.Blood eosinophils,sex and BMI were not significantly correlated with serum 25(OH)D in COPD.ConclusionVitamin D deficiency in healthy population and COPD patients was universal.The relationship between vitamin D level and sex,BMI and blood eosinophils is inconsistent in health and disease state.