Clinical Study On Electroacupuncture Combined With Mecobalamin In The Treatment Of Chemotherapy-induced Peripheral Neuropathy In Multiple Myeloma

Objective:To observe the efficacy and safety of electroacupuncture combined with mecobalamin in the treatment of multiple myeloma chemotherapy-related peripheral neuropathy at Grade 2 and above,and to investigate the effective evaluation method of chemotherapy-related peripheral neuropathy in multiple myeloma.Methods:From November 2015 to September 2017,42 patients with MMwho were hospitalized for chemotherapy in the Department of Hematology of Gansu Provincial People's Hospital met the entry criteria and were randomly divided into two groups.Among them,21 patients in the control group with mecobalamin alone were given intramuscular injection of mecobalamin injection,0.5 mg/time,once daily for a total of 2 weeks.Electroacupuncture combined with mecobalamin treatment group 21 cases,in the control group treatment program based on the addition of electro-acupuncture treatment,20 min / time,1 / day,5 times / course of treatment,after the end of a course of treatment,interval 2 days,continue to 2 courses of treatment,a total of 2 courses of treatment.NRS pain score,FACT/GOG-NTX neurotoxicity rating scale,and nerve conduction velocity(NCV)were used to evaluate peripheral neuropathy in both groups before and after treatment.Record adverse reactions during treatment.Results:1.The control group and the treatment group matched the baseline data of gender,age,classification of peripheral neuropathy,etc.,and there was no statistical significance(P>0.05);The two groups of patients before treatment evaluation index of peripheral neuropathy(NRS pain score,The scores of FACT/GOG-Ntx quality of life questionnaires and nerve conduction velocity(NCV)were not statistically significant(P>0.05).The two groups were comparable.2.After 2 courses of treatment,the results of peripheral neuropathy assessment indicators(NRS pain score,FACT/GOG-Ntx quality of life questionnaire score,andnerve conduction velocity(NCV))of the control group and the treatment group were significantly improved.Before and after the evaluation of the peripheral neuropathy assessment index was statistically significant(P <0.05).3.Compared with the two groups after treatment,the improvement of peripheral neuropathy in the treatment group was better than that in the control group,and the difference between the two groups was statistically significant(P < 0.05).4.Through the evaluation of adverse events,patient compliance and treatment safety in the treatment process,the treatment regimen is well tolerated and there are no adverse events.It is safe and effective.Conclusions:1.The subjective scales(the FACT/GOG-Ntx neurotoxicity assessment tool and the NRS pain rating scale)and the objective index(nerve conduction velocity(NCV))used in this clinical trial can provide a comprehensive and effective assessment of peripheral neuropathy.2.Electro-acupuncture treatment can significantly reduce the pain score and quality of life score of patients with chemotherapy-related PN,improve the nerve conduction velocity of patients,and improve the peripheral neuropathy better than that of mecobalamin alone.3.Through the evaluation of adverse events,patient compliance,and treatment safety in the treatment process,the treatment regimen is well tolerated and there are no adverse events.It is safe and effective.The treatment of multiple myeloma chemotherapy related peripheral neuropathy has great potential,it is worthy of clinical promotion and further research.