The Clinical Research On Serum Inflammatory Factor Level From Essential Hypertenion By The Intervention Of Kidney And Liver Nourising Soup

Objectives By observing the blood pressure lowering level,serum inflammatory factor level,TCM syndromes integral and other related indexes of treating essential hypertension with yin deficiency and yang hyperactivity,the clinical safety of Zishenyugan decoction was detected.It is proved that Zishen Rugan decoction is effective and safe in lowering blood pressure,improving inflammatory reaction of essential hypertension and TCM syndrome.Methods By using the method of computer random,positive drug control,the general information of the patients was collected,and the blood pressure was measured three times within a week instead of the same day,and the patients who met the criteria of hyperactivity of yin deficiency and yang were included in the standard,and the patients who were not included in the exclusion criteria were measured three times in a week.Those whose final monitoring results met the inclusion criteria were included in the group.The control group was treated with nifedipine sustained release 10 mg bid.On the basis of this,the experimental group was treated with Zishen Rugan decoction.Two months were used as a course of study in both groups.The serum levels of CRP IL-6 and TNF-? were measured before and after treatment,and the antihypertensive efficacy and safety of the two groups were evaluated.The data obtained by the statistical software SPSS13.0 are used for statistical analysis.Results In this study,150 patients were selected from the first traditional Chinese Medicine Hospital of Baoding City,including 2 cases of shedding,2 cases of shedding,2 cases of knockout,2 cases of knockout and 1.33% of knockout.The statistical data of these 148 cases(including 2 cases of shedding)were analyzed.There was no significant difference in sex,age,course of disease and complications between the two groups before treatment(P>0.05).1)The difference of systolic blood pressure between the test group and the control group was 45.50±13.31 and 20.64±8.09,respectively.The difference of diastolic blood pressure was 37.63±15.18 and 15.09±6.45,respectively.There was significant difference between the experimental group and the control group before and after treatment(P<0.05),and there was significant difference between the two groups(P< 0.05).2)parameters of ambulatory blood pressure: The average systolic and diastolic blood pressure and diastolic blood pressure in daytime,night and 24 h after treatment were significantly lower than those in the control group before and during the day,night and 24 h after treatment(P<0.05).There was no difference in the values between the two groups(P< 0.05).Therefore,the effects of the test group and the control group on the indexes of systolic and diastolic blood pressure were significantly lower than those in the control group during the day,night and 24 h,and the systolic and diastolic blood pressure during the day and night of the experimental group were significantly lower than those in the control group.There was significant difference in systolic blood pressure and diastolic blood pressure load between the two groups(P>0.05).3)the effective rate of hypotension: In the test group,66 cases were obviously effective in lowering blood pressure,8 cases were effective,the total effective rate was 100,55 cases in the control group,15 cases in the control group and 4 cases without any effect,the total effective rate was 94.6%.4)The inflammatory response was improved : After treatment,the levels of inflammatory factors in the experimental group and the control group were significantly different after treatment(P>0.05),but there was no significant difference between the test group and the IL-6 inflammatory factor group(P>0.05).5)TCM syndrome score: After treatment,the scores of TCM symptoms in the experimental group and the control group were all decreased,the symptoms of TCM were improved,and the difference was statistically significant(P< 0.05).There were significant differences in symptom score and difference between the two groups after treatment(P<0.01).6)improve the effective rate of TCM symptoms:In the improvement of TCM symptoms,there was a significant difference between the experimental group and the control group in two aspects(P>0.05).The total effective rate was 93.27 in the experimental group and 59.46 th in the control group.In terms of individual symptoms of TCM,the effective rate of the experimental group with vertigo,headache,lumbar acid,palpitation and other symptoms was higher than that of the control group,and the improvement of symptoms of vertigo,headache,five-upset heat,insomnia,tinnitus,etc.The experimental group was significantly better than the control group(P< 0.01),but there was no significant difference in amnesia between the two groups(P> 0.01).7)Security comparison:There were 1 case in the trial group and 3 cases in the control group.There was no significant difference between the two groups(P>0.05).Conclusions The therapeutic effect of Zishenyugan decoction combined with western medicine on lowering blood pressure is obviously superior to that of western medicine alone.It can reduce the level of inflammatory factors in the serum of patients with essential hypertension and alleviate the TCM symptoms of hypertension with yin deficiency and hyperactivity of yang.It is an effective and safe drug for the treatment of essential hypertension(yin deficiency and yang hyperactivity).