| Purpose: To observe the clinical effect of Ziyin Qianyang Anshen Decoction on insomnia of Parkinson's disease of Yin deficiency and Yang hyperactivity.Methods: This study was based on 60 patients with Parkinson's insomnia who visited the Department of Encephalopathy,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2017 to December 2018.According to the inclusion criteria and exclusion criteria,60 patients were selected and randomly divided into experimental group and control group with 30 cases in each group.Both groups were treated with basic anti-Parkinson's disease drugs.The experimental group was treated with Ziyin Qianyang Anshen Decoction,and the control group was treated with right zopiclone tablets for 4 weeks.Before and after treatment,Pittsburgh Sleep Quality Index(PSQI),Unified Parkinson's Disease Score Scale Part III(UPDRS-III),Parkinson's Disease Quality of Life Questionnaire 39(PDQ-39)and Chinese Medicine Syndrome Scale were used to evaluate the sleep status,Parkinson's disease motor symptoms,quality of life,clinical symptoms of Chinese medicine and clinical efficacy of the two groups.SPSS20.0 was used for statistical analysis.Results: 1.Before treatment,there was no significant difference in PSQI score,UPDRS-III score,PDQ-39 score and TCM syndrome score between the two groups(P > 0.05),suggesting that the two groups were comparable.2.After treatment,the PSQI scores of the two groups were lower than those before treatment(P < 0.05),and the experimental group was better than the control group(P < 0.05);UPDRS-III scores of the two groups were lower than those before treatment(P < 0.05),while the control group was not significantly lower than that before treatment(P > 0.05),the experimental group was better than the control group(P < 0.05);PDQ-39 scores of the two groups were lower than those before treatment(P < 0.05),and the test group was better than that of the control group(P < 0.05).The scores of TCM syndromes in the two groups were lower than those before treatment(P < 0.05),and the experimental group was better than the control group(P < 0.05).3.Compared the efficacy of sleep quality and TCM syndromes,the experimental group was better than the control group(P < 0.05).Conclusion: 1.Ziyin Qianyang Anshen Decoction can effectively improve sleep quality,clinical symptoms and quality of daily life of insomnia patients with Parkinson's disease of yin deficiency and Yang hyperactivity,and its effect is better than that of right zopiclone tablet.2.Ziyin Qianyang Anshen Decoction can also effectively improve the motor symptoms of Parkinson's disease in patients with insomnia due to Yin deficiency and Yang hyperactivity,but the improvement of right zopiclone tablet is not obvious. |
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