| Objective: To investigate the efficacy and prognosis of tanshinone combined with red light and drug mask in the treatment of mild-moderate acne,as well as the impact on the quality of life of patients.Methods: A total of 40 patients with mild-moderate acne at our dermatology clinic from September 2017 to December 2017 were selected and divided into experimental group(20 cases)and control group(20 cases).Before the treatment,we asked the basic situation of patients in details,and explain the process of treatment and the precautions to the patients.The experimental group was treated with oral tanshinone capsules combined with red light and drug mask comprehensive treatment,the control group was treated with red light and drug mask comprehensive treatment.The course of treatment was 4 weeks.Before treatment,2 weeks and 4 weeks,the two groups were photographed by the same dermatologist,and record the patient's clinical symptoms and signs.And the patients were asked to fill in the DLQI questionnaire to assess patient quality of life.All photographs were scored by the same dermatologist using the Pillsbury International Grading Method and GAGS score.One month after treatment,follow-up was performed to observe the relapse and aggravating conditions.More than 10 new rashes in the cured patients were recorded as recurrence,and the total lesion increased more than 10 comparing of the end of treatment were recorded as aggravating.Results:(1)Etiology analysis: About 37.5% of the patients do not pay attention to sun protection or moisturizing.There were 22.5% of the patients had the habit of drinking milk daily,65% of the patients prefer pastry sweets,55% prefer spicy foods,followed by savory and greasy foods.All patients spent about(6.18 ± 3.38)h/d on computer or mobile phone.(2)The baseline balance comparison of two groups: There was no significant difference in age,sex,duration of disease,Pillsbury grade and GAGS scores between the two groups(P>0.05).(3)Comparison of efficacy: After 4 weeks of treatment,the marked effective rate was 70%.Among the 20 patients the marked effective rate was 35%.The marked effective rate in the experimental group was obviously higher than that in the control group(P< 0.05).(4)GAGS score comparison: Before treatment,GAGS score was(24.60 ± 5.26)in the experimental group and(23.20 ± 4.99)in the control group,with no significant difference between the two groups(P>0.05).At 2 weeks of treatment,the GAGS score of the experimental group was decreased(5.55±3.61)points,while the GAGS score of the control group was decreased by(6.20 ± 4.99)on average.There was no significant difference between the two groups(P>0.05).After treatment,the GAGS score in the experimental group decreased by an average of(10.70 ± 4.99)points,which was significantly higher than that in the control group(7.25 ± 4.24)points(P<0.05).(5)DLQI score comparison: Before treatment,the DLQI score was(11.50 ± 3.85)points in the experimental group and(9.30 ± 4.77)points in the control group,with no significant difference between the two groups(P>0.05).After treatment,the DLQI score was(5.30 ± 2.52)points in the experimental group and(4.45 ± 2.24)points in the control group,with no significant difference between the two groups(P>0.05).The decreased DLQI score of the experimental group was(6.20 ± 2.88)points and lower than that of the control group(4.85 ± 3.17)points,with no significant difference between the two groups(P>0.05).(6)Adverse reactions: There were 4 cases(20%)in the experimental group and 3 cases(15%)in the control group,with no significant difference between the two groups(P>0.05).Adverse reactions were mild in both groups,patients were tolerated,and no termination of treatment events,caused by the adverse events.(7)Prognosis: Follow-up after 1 month of treatment,3 cases of exacerbation or recurrence occurred in the experimental group,4 cases in the control group,and the recurrence and exacerbations were mild in both groups.There was no significant difference between the two groups(P> 0.05).The relapse and exacerbations of patients were minor in both groups,compared with the end of the treatment,the number of new lesions increased among 10 to 15,and there were no patients worse than before treatment.Conclusion:(1)Most acne patients like to eat spicy and sweet,followed by salty and greasy food.(2)Tanshinone combined with red light and drug mask comprehensive treatment is better than red light and drug mask comprehensive treatment.(3)Tanshinone combined with red light and drug mask comprehensive treatment can significantly improve the severity of acne patients and quality of life.There was no significant difference in safety.It is worth clinical promotion. |
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